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Article: Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Schuster JE; Fu R; Siddique T; Heckman CJ J. Neurophysiol., 2012
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Other | Spinal Cord Motor Neuron | cell capacitance (pF) | 30.4 ± 17.5 (57) | 30.4 (pF) | Data Table |
| Other | Spinal Cord Motor Neuron | cell diameter (μm) | 25.7 ± 4.9 (57) | 25.7 (um) | Data Table |
| Other | Spinal Cord Motor Neuron | FI slope (Hz/pA) | 0.24 ± 0.09 (56) | 240.0 (Hz/nA) | Data Table |
| Other | Spinal Cord Motor Neuron | firing frequency | 71.5 ± 152.0 (19) | 71.5 (Hz) | Data Table |
| Other | Spinal Cord Motor Neuron | resting membrane potential (mV) | -50.5 ± 6.4 (57) | -50.5 (mV) | Data Table |
| Other | Spinal Cord Motor Neuron | rheobase (pA) | 26.8 ± 41.6 (56) | 26.8 (pA) | Data Table |
| Other | Spinal Cord Motor Neuron | spike peak | 32.4 ± 6.8 (57) | 32.4 (mV) | Data Table |
| Other | Spinal Cord Motor Neuron | spike threshold (mV) | -31.7 ± 3.8 (57) | -31.7 (mV) | Data Table |
Metadata values
| Experimental condition | Value |
|---|---|
| Species | Mice |
| ElectrodeType | Patch-clamp |
| RecTemp | 20.0 - 24.0 |
| PrepType | cell culture |
| Strain | Other |
| AnimalAge | 12.0 - 14.0 |
| InternalSolution | 5.0 |
| ExternalSolution | 5.0 |
| JxnPotential | Unreported |
| internal_0_pH | 7.3 |
| internal_0_Mg | 7.0 |
| internal_0_K | 145.0 |
| internal_0_ATP | 5.0 |
| internal_0_EGTA | 1.1 |
| internal_0_HEPES | 5.0 |
| internal_0_Cl | 4.2 |
| internal_0_Ca | 0.1 |
| external_0_pH | 7.4 |
| external_0_Mg | 1.5 |
| external_0_Na | 153.2 |
| external_0_K | 3.0 |
| external_0_Cl | 134.0 |
| external_0_Ca | 2.5 |
| external_0_glucose | 10.0 |
Data table listing
| Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
|---|---|---|---|---|---|---|---|---|
| 10762 | Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS. | Schuster JE; Fu R; Siddique T; Heckman CJ | J. Neurophysiol. | 2012 | False | 8 | Shreejoy Tripathy, Ryan Sefidpour, Athanasios Kritharis, | 1 |
| 10763 | Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS. | Schuster JE; Fu R; Siddique T; Heckman CJ | J. Neurophysiol. | 2012 | False | 1 | 0 |