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Article: Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Curia G; Aracri P; Sancini G; Mantegazza M; Avanzini G; Franceschetti S
Neuroscience, 2004

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 input resistance (MΩ) 34.1 ± 3.2 (5) 34.1 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 membrane time constant (ms) 10.7 ± 0.3 (5) 10.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 rheobase (nA) 0.19 ± 0.04 (5) 190.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 spike amplitude (mV) 103.7 ± 3.3 (5) 103.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 spike max decay slope (V/s) 115.8 ± 12.0 (5) 115.8 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 spike max rise slope (V/s) 322.1 ± 23.0 (5) 322.1 (mV/ms) Data Table

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Metadata values

Experimental condition Value
Species Rats
PrepType in vitro
Strain Sprague-Dawley
ElectrodeType Sharp
AnimalAge 10.0 - 45.0
JxnPotential Not corrected
RecTemp 35.0
InternalSolution 5.0
ExternalSolution 5.0
internal_0_K 3000.0
external_0_Mg 2.0
external_0_Na 151.75
external_0_K 3.5
external_0_Cl 131.5
external_0_Ca 2.0
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
21238 Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents. Curia G; Aracri P; Sancini G; Mantegazza M; Avanzini G; Franceschetti S Neuroscience 2004 False 6 Ryan Sefidpour, 5
21237 Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents. Curia G; Aracri P; Sancini G; Mantegazza M; Avanzini G; Franceschetti S Neuroscience 2004 False 0 None