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Article: Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Drew LJ; Stark KL; Fénelon K; Karayiorgou M; Macdermott AB; Gogos JA
Mol. Cell. Neurosci., 2011

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell cell capacitance (pF) 107.1 ± 4.9 (16) 107.1 (pF) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 147.8 ± 11.8 (16) 147.8 (MΩ) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -64.1 ± 1.1 (16) -64.1 (mV) Data Table
Hippocampus CA1 pyramidal cell rheobase (pA) 88.13 ± 8.27 (7) 88.13 (pA) Data Table
Hippocampus CA1 pyramidal cell sag ratio 0.86 ± 0.01 (16) 0.86 (ratio) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -45.4 ± 0.7 (13) -45.4 (mV) Data Table

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Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
PrepType in vitro
Strain C57BL
ExternalSolution 5.0
InternalSolution 5.0
internal_1_Mg 4.0
internal_1_Na 4.6
internal_1_Cl 9.0
JxnPotential Not corrected
AnimalAge 35.0 - 42.0
RecTemp 31.0 - 32.0
internal_0_Mg 4.0
internal_0_Na 29.6
internal_0_K 140.0
internal_0_GTP 0.3
internal_0_ATP 4.0
internal_0_EGTA 0.1
internal_0_HEPES 10.0
internal_0_Cl 19.0
external_0_Mg 1.0
external_0_Na 150.0
external_0_K 2.5
external_0_Cl 130.5
external_0_Ca 2.0
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
25261 Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion. Drew LJ; Stark KL; Fénelon K; Karayiorgou M; Macdermott AB; Gogos JA Mol. Cell. Neurosci. 2011 False 6 Shreejoy Tripathy, Kerrie Tsigounis, Athanasios Kritharis, 2