AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Wang Y; Kuehl-Kovarik MC
Brain Res., 2012

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Hypothalamus GnRH-expressing estradiol-treated neuron ADP amplitude (mV) 4.07 ± 0.53 -- Data Table
Other Hypothalamus GnRH-expressing neuron. ADP amplitude (mV) 4.66 ± 0.23 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) ADP amplitude (mV) 6.27 ± 0.62 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) ADP amplitude (mV) 4.79 ± 0.68 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron ADP amplitude (mV) 3.51 ± 0.41 -- Data Table
Other Hypothalamus GnRH-expressing neuron. ADP amplitude (mV) 4.68 ± 0.26 4.68 (mV) Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) ADP amplitude (mV) 4.19 ± 0.28 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) ADP amplitude (mV) 3.51 ± 0.51 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron AHP amplitude (mV) -4.35 ± 0.44 -- Data Table
Other Hypothalamus GnRH-expressing neuron. AHP amplitude (mV) -4.65 ± 0.55 4.65 (mV) Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) AHP amplitude (mV) -4.3 ± 0.27 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) AHP amplitude (mV) -3.2 ± 0.82 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron AHP amplitude (mV) -3.82 ± 0.46 -- Data Table
Other Hypothalamus GnRH-expressing neuron. AHP amplitude (mV) -4.48 ± 0.54 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) AHP amplitude (mV) -4.46 ± 0.09 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) AHP amplitude (mV) -3.82 ± 1.05 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike amplitude from resting (mV) 125.4 ± 3.42 -- Data Table
Other Hypothalamus GnRH-expressing neuron. spike amplitude from resting (mV) 128.6 ± 1.07 128.6 (mV) Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike amplitude from resting (mV) 125.4 ± 1.5 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike amplitude from resting (mV) 126.5 ± 1.67 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike amplitude from resting (mV) 129.1 ± 1.17 -- Data Table
Other Hypothalamus GnRH-expressing neuron. spike amplitude from resting (mV) 126.8 ± 2.39 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike amplitude from resting (mV) 131.9 ± 0.9 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike amplitude from resting (mV) 126.2 ± 2.0 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike half-width 1.5 ± 0.07 -- Data Table
Other Hypothalamus GnRH-expressing neuron. spike half-width 1.53 ± 0.07 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike half-width 1.65 ± 0.08 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike half-width 1.72 ± 0.12 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike half-width 1.64 ± 0.13 -- Data Table
Other Hypothalamus GnRH-expressing neuron. spike half-width 1.55 ± 0.07 1.55 (ms) Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike half-width 1.53 ± 0.15 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike half-width 1.46 ± 0.05 -- Data Table

Report miscurated data

Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
PrepType in vitro
PrepType cell culture
Strain Mouse, Transgenic
InternalSolution 5.0
ExternalSolution 5.0
RecTemp 22.0
JxnPotential Unreported
AnimalAge 90.0
internal_0_pH 7.3
internal_0_Mg 1.0
internal_0_Na 1.0
internal_0_K 120.0
internal_0_GTP 0.2
internal_0_ATP 2.0
internal_0_EGTA 5.0
internal_0_HEPES 10.0
internal_0_Cl 5.0
internal_0_Ca 1.0
external_0_pH 7.4
external_0_Mg 2.0
external_0_Na 151.25
external_0_K 3.0
external_0_Cl 127.2
external_0_Ca 0.1
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
26387 Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons. Wang Y; Kuehl-Kovarik MC Brain Res. 2012 False 4 Shreejoy Tripathy, Nathalie Binnion, Ryan Sefidpour, 1