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Article: Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Sancini G; Franceschetti S; Lavazza T; Panzica F; Cipelletti B; Frassoni C; Spreafico R; Acampora D; Avanzini G
Eur. J. Neurosci., 2001

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron input resistance (MΩ) 56.3 ± 6.6 (9) 56.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron input resistance (MΩ) 87.2 ± 9.6 (16) 87.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron membrane time constant (ms) 8.1 ± 0.6 (9) 8.1 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron membrane time constant (ms) 9.5 ± 0.62 (16) 9.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron resting membrane potential (mV) -63.8 ± 0.7 (16) -63.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron resting membrane potential (mV) -65.5 ± 1.1 (9) -65.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike amplitude (mV) 90.4 ± 2.9 (9) 90.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike amplitude (mV) 89.8 ± 3.6 (16) 89.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike max rise slope (V/s) 198.7 ± 13.2 (16) 198.7 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike max rise slope (V/s) 223.1 ± 12.1 (9) 223.1 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike threshold (mV) -50.9 ± 1.8 (9) -50.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike threshold (mV) -48.6 ± 1.1 (16) -48.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike width (ms) 1.78 ± 0.06 (16) 1.78 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike width (ms) 1.37 ± 0.06 (9) 1.37 (ms) Data Table

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Metadata values

Experimental condition Value
PrepType in vitro
AnimalAge 17.0 - 200.0
ExternalSolution 5.0
Species Mice
Strain Other
JxnPotential Unreported
RecTemp 35.0
InternalSolution 5.0
ElectrodeType Sharp
internal_0_pH 7.3
internal_0_K 750.0
external_0_pH 7.35
external_0_Mg 2.0
external_0_Na 153.2
external_0_K 3.5
external_0_Cl 133.5
external_0_Ca 2.0
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
45375 Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice. Sancini G; Franceschetti S; Lavazza T; Panzica F; Cipelletti B; Frassoni C; Spreafico R; Acampora D; Avanzini G Eur. J. Neurosci. 2001 False 7 Shreejoy Tripathy, Patrick Savage, 1
45376 Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice. Sancini G; Franceschetti S; Lavazza T; Panzica F; Cipelletti B; Frassoni C; Spreafico R; Acampora D; Avanzini G Eur. J. Neurosci. 2001 False 2 0