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Article: Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Taneja P; Ogier M; Brooks-Harris G; Schmid DA; Katz DM; Nelson SB
J. Neurosci., 2009

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Locus coeruleus noradrenergic neuron adaptation ratio 0.6 (36) 0.6 (ratio) Data Table
Locus coeruleus noradrenergic neuron AHP amplitude (mV) -24.4 ± 0.7 (36) 24.4 (mV) Data Table
Locus coeruleus noradrenergic neuron cell capacitance (pF) 130.0 ± 4.0 (36) 130.0 (pF) Data Table
Locus coeruleus noradrenergic neuron cell surface area (um^2) 332.0 ± 6.0 (36) -- Data Table
Locus coeruleus noradrenergic neuron FI slope (Hz/pA) 0.06 (36) 60.0 (Hz/nA) Data Table
Locus coeruleus noradrenergic neuron input resistance (Mohm) 430.0 ± 30.0 (36) 430.0 (MΩ) Data Table
Locus coeruleus noradrenergic neuron resting membrane potential (mV) -43.1 ± 0.7 (36) -43.1 (mV) Data Table
Locus coeruleus noradrenergic neuron spike threshold (mV) -29.4 ± 0.6 (36) -29.4 (mV) Data Table
Locus coeruleus noradrenergic neuron spontaneous firing rate (Hz) 0.8 ± 0.1 (36) 0.8 (Hz) Data Table

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Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
PrepType in vitro
Strain C57BL
RecTemp 32.0
Strain BALB C
AnimalAge 26.0 - 28.0
InternalSolution 5.0
ExternalSolution 5.0
JxnPotential Not corrected
JxnOffset -14.0
internal_0_pH 7.35
internal_0_Mg 4.0
internal_0_Na 10.3
internal_0_K 120.0
internal_0_GTP 0.3
internal_0_ATP 4.0
internal_0_HEPES 10.0
internal_0_Cl 20.0
external_0_pH 7.4
external_0_Mg 1.0
external_0_Na 152.2
external_0_K 2.5
external_0_Cl 134.7
external_0_Ca 2.1
external_0_glucose 32.6

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
50016 Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome. Taneja P; Ogier M; Brooks-Harris G; Schmid DA; Katz DM; Nelson SB J. Neurosci. 2009 False 9 Shreejoy Tripathy, Ryan Sefidpour, 1