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Article: The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Ovsepian SV; Friel DD Eur. J. Neurosci., 2008
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Cerebellum Purkinje cell | AHP amplitude (mV) | 8.2 ± 1.1 (17) | 8.2 (mV) | Data Table | |
| Cerebellum Purkinje cell | spike half-width (ms) | 0.42 ± 0.04 (17) | 0.42 (ms) | Data Table | |
| Cerebellum Purkinje cell | spike max decay slope (V/s) | 331.0 ± 9.0 (17) | 331.0 (mV/ms) | Data Table | |
| Cerebellum Purkinje cell | spike max rise slope (V/s) | 288.0 ± 12.1 (17) | 288.0 (mV/ms) | Data Table | |
| Cerebellum Purkinje cell | spike peak (mV) | 66.2 ± 3.1 (17) | 66.2 (mV) | Data Table |
Metadata values
| Experimental condition | Value |
|---|---|
| Species | Mice |
| ElectrodeType | Patch-clamp |
| PrepType | in vitro |
| Strain | C57BL |
| Strain | Mouse, Transgenic |
| RecTemp | 32.0 - 34.0 |
| AnimalAge | 16.0 - 21.0 |
| JxnPotential | Not corrected |
| ExternalSolution | 5.0 |
| InternalSolution | 5.0 |
| internal_1_pH | 7.3 |
| internal_1_Mg | 4.6 |
| internal_1_Na | 0.3 |
| internal_1_Cl | 139.2 |
| internal_0_pH | 7.3 |
| internal_0_Mg | 2.0 |
| internal_0_Na | 5.0 |
| internal_0_K | 150.0 |
| internal_0_ATP | 2.0 |
| internal_0_EGTA | 0.01 |
| internal_0_HEPES | 10.0 |
| internal_0_Cl | 15.0 |
| external_0_Mg | 2.0 |
| external_0_Na | 151.25 |
| external_0_K | 2.5 |
| external_0_Cl | 135.5 |
| external_0_Ca | 2.0 |
| external_0_Cs | 33.0 |
| external_0_glucose | 25.0 |
Data table listing
| Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
|---|---|---|---|---|---|---|---|---|
| 17398 | The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts. | Ovsepian SV; Friel DD | Eur. J. Neurosci. | 2008 | True | 5 | Shreejoy Tripathy, Ryan Sefidpour, | 1 |
| 17399 | The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts. | Ovsepian SV; Friel DD | Eur. J. Neurosci. | 2008 | False | 0 | None |