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Article: Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Proulx É; Fraser P; McLaurin J; Lambe EK J. Neurosci., 2015
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 5-6 | prefrontal cortex layer 6 pyramidal neuron | cell capacitance (pF) | 72.0 ± 2.0 | 72.0 (pF) | Data Table |
| Neocortex pyramidal cell layer 5-6 | prefrontal cortex layer 6 pyramidal neuron | input resistance (MΩ) | 313.0 ± 18.0 | 313.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | prefrontal cortex layer 6 pyramidal neuron | resting membrane potential (mV) | -83.0 ± 1.0 | -83.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | prefrontal cortex layer 6 pyramidal neuron | spike amplitude (mV) | 79.0 ± 1.0 | 79.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | prefrontal cortex layer 6 pyramidal neuron | spike threshold (mV) | -52.0 ± 0.4 | -52.0 (mV) | Data Table |
Metadata values
| Experimental condition | Value |
|---|---|
| Species | Mice |
| ElectrodeType | Patch-clamp |
| PrepType | in vitro |
| ExternalSolution | 5.0 |
| InternalSolution | 5.0 |
| Strain | C57BL |
| JxnPotential | Unreported |
| AnimalAge | 109.0 ± 2.0 |
| RecTemp | 30.0 |
| internal_0_pH | 7.33 |
| internal_0_Mg | 2.0 |
| internal_0_Na | 20.8 |
| internal_0_K | 129.0 |
| internal_0_GTP | 0.4 |
| internal_0_ATP | 4.0 |
| internal_0_HEPES | 10.0 |
| internal_0_Cl | 9.0 |
| external_0_pH | 7.4 |
| external_0_Mg | 2.0 |
| external_0_Na | 155.25 |
| external_0_K | 3.0 |
| external_0_Cl | 135.0 |
| external_0_Ca | 2.0 |
| external_0_glucose | 10.0 |
Data table listing
| Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
|---|---|---|---|---|---|---|---|---|
| 47329 | Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease. | Proulx É; Fraser P; McLaurin J; Lambe EK | J. Neurosci. | 2015 | False | 5 | Shreejoy Tripathy, James liu, | 1 |