|
Article: Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Hurlock EC; McMahon A; Joho RH J. Neurosci., 2008
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Cerebellum Purkinje cell | FI slope (Hz/200 pA) | 29.3 ± 3.19 | -- | Data Table | |
| Cerebellum Purkinje cell | input resistance (MΩ) | 23.3 ± 0.83 | 23.3 (MΩ) | Data Table | |
| Cerebellum Purkinje cell | maximum firing rate (Hz) | 625.0 ± 39.0 | 625.0 (Hz) | Data Table | |
| Cerebellum Purkinje cell | spike half-width (ms) | 0.15 ± 0.004 | 0.15 (ms) | Data Table |
Metadata values
| Experimental condition | Value |
|---|---|
| RecTemp | 35.0 ± 0.5 |
| AnimalAge | 40.0 - 95.0 |
| Strain | C57BL |
| PrepType | in vitro |
| ElectrodeType | Patch-clamp |
| Species | Mice |
| InternalSolution | 5.0 |
| ExternalSolution | 5.0 |
| JxnPotential | Unreported |
| Strain | Other |
| internal_0_Mg | 0.3 |
| internal_0_Na | 7.5 |
| internal_0_K | 130.0 |
| internal_0_GTP | 0.5 |
| internal_0_ATP | 2.0 |
| internal_0_EGTA | 0.1 |
| internal_0_HEPES | 10.0 |
| internal_0_Cl | 7.6 |
| external_0_Mg | 1.5 |
| external_0_Na | 150.0 |
| external_0_K | 3.25 |
| external_0_Cl | 134.25 |
| external_0_Ca | 1.5 |
| external_0_glucose | 25.0 |
Data table listing
| Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
|---|---|---|---|---|---|---|---|---|
| 2069 | Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants. | Hurlock EC; McMahon A; Joho RH | J. Neurosci. | 2008 | False | 4 | Shreejoy Tripathy, Patrick Savage, Cindy-Lee Crichlow, Athanasios Kritharis, | 4 |