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Article: Calcium dynamics and electrophysiological properties of cerebellar Purkinje cells in SCA1 transgenic mice.

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Inoue T; Lin X; Kohlmeier KA; Orr HT; Zoghbi HY; Ross WN
J. Neurophysiol., 2001


Table 1.

Slower Na+ spike kinetics in SCA1 Purkinje cells

Na+ Spike Just Above Threshold 10th Na+ Spike in a Burst
Wild type (n = 28) SCA1 (n = 29) Wild type (n = 23) SCA1 (n = 26)
Width (half height), ms 0.234 ± 0.046 0.405 ± 0.158† 0.234 ± 0.058 0.388 ± 0.118†
Rising phase
 10–90% time, ms 0.170 ± 0.032 0.429 ± 0.452† 0.161 ± 0.029 0.330 ± 0.333*
 Maximum slope, mV/ms 364 ± 81 242 ± 135† 406 ± 89 295 ± 133†
Falling phase
 90–10% time, ms 0.158 ± 0.039 0.266 ± 0.092† 0.162 ± 0.047 0.319 ± 0.136†
 Maximum slope, mV/ms −318 ± 78 −181 ± 78† −334 ± 94 −189 ± 85†

  • All of the kinetic parameters were significantly different between SCA1 and wild-type Purkinje cells for the first Na+spikes evoked just above threshold and for Na+ spikes in the middle of the train (10th Na+ spike). Results are indicated as means ± SD (* P < 0.03, † P < 0.01, t-test).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Purkinje cell spike rise time (ms) 0.17 ± 0.032 (28) 0.17 (ms) Data Table
Cerebellum Purkinje cell spike max rise slope (mV/ms) 364.0 ± 81.0 (28) 364.0 (mV/ms) Data Table
Cerebellum Purkinje cell spike half-width 0.234 ± 0.046 (28) 0.234 (ms) Data Table
Cerebellum Purkinje cell spike decay time (ms) 0.158 ± 0.039 (28) 0.158 (ms) Data Table
Cerebellum Purkinje cell spike max decay slope (mV/ms) -318.0 ± 78.0 (28) 318.0 (mV/ms) Data Table