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Article: GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.

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Patrylo PR; Spencer DD; Williamson A
J. Neurophysiol., 2001


Table 4.

IPSP conductances are reduced in granule cells from epileptic rats

No. of Cells Saline-Treated Controls 11 KA-Treated 10 Significance
E fast IPSP, mV −60.0 ± 1.93 −62.0 ± 1.93
E slow IPSP, mV −86.3 ± 1.96 −88.5 ± 2.59
G fast IPSP, nS 8.18 ± 1.05 5.18 ± 0.64 0.023
G slow IPSP, nS 2.41 ± 0.37 0.84 ± 0.19 0.001

  • There were significant differences between the conductances of the fast and slow inhibitory postsynaptic potentials (IPSPs) between control and KA-treated rats. There were no differences in the reversal potential for the fast and slow IPSPs.


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