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Article: Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Schuster JE; Fu R; Siddique T; Heckman CJ
J. Neurophysiol., 2012


Table 2.

PIC, NaPIC, and TTX-ins measures

Measure Significance Direction wt 0 μΜ SOD1 0 μΜ wt 2 μΜ SOD1 2 μΜ
PIC N = 46 N = 25 N = 51 N = 30
    Onset, mV Drug** 0 > 2 −42.5 ± 5.0 −45.5 ± 3.0 −46.1 ± 5.1 −46.2 ± 3.9
Genotype* wt > SOD1
    Max voltage, mV Drug**** 0 > 2 −28.5 ± 4.7 −29.0 ± 2.6 −32.0 ± 4.1 −32.1 ± 3.1
    Amplitude, pA Drug** 0 < 2 −36.8 ± 28.6 −57.9 ± 58.7 −33.8 ± 25.3 −25.8 ± 18.9
Interaction** SOD1: 0 < 2
SOD1 0 < wt 2
NaPIC N = 35 N = 20 N = 39 N = 22
    Onset, mV Drug* 0 > 2 −48.6 ± 6.6 −49.2 ± 3.9 −51.5 ± 3.5 −50.4 ± 4.4
    Max voltage, mV Drug* 0 > 2 −24.5 ± 4.8 −26.0 ± 3.8 −26.7 ± 4.4 −28.0 ± 5.4
    Amplitude, pA Ns −74.7 ± 45.3 −73.9 ± 41.8 −68.3 ± 25.4 −56.6 ± 27.7
TTX-ins N = 30 N = 20 N = 38 N = 21
    Onset, mV Genotype** wt < SOD1 −53.4 ± 12.9 −45.7 ± 8.8 −54.0 ± 11.0 −48.1 ± 13.4
    Amp, PIC max Genotype* wt > SOD1 43.9 ± 30.3 28.7 ± 14.5 45.1 ± 49.2 32.1 ± 23.0
  • Means ± SD for each of the 4 individual groups are presented separately (genotype:drug): wt control (0 μM), SOD1 control (0 μN), wt riluzole (2 μM), and SOD1 riluzole (2 μM). The number of cells per group (N) is above each series of measurements. PIC, persistent inward current; NaPIC, sodium PIC; TTX-ins, TTX-insensitive current; Amp, amplitude. Significant differences for drug, genotype and interactions are listed in a separate column. Significance: not significant (ns),

  • * 0.05 ≥ P > 0.01,

  • ** 0.01 ≥ P > 0.001,

  • **** P ≤ 0.0001. The direction of each significant difference is listed in a separate column. The direction is based on actual, not absolute, values.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source