Cortical firing rates in response to sinusoidally modulated, simulated M/T population currents: mean cortical firing rate
| Simulated respiratory rhythm | ||||||
|---|---|---|---|---|---|---|
| 2 Hz rhythm | 8 Hz rhythm | |||||
| Plasticity | ||||||
| F | FD | D | F | FD | D | |
| M/T FR (Hz) | ||||||
| 12 | 6.3 ± 1.1 | 5.3 ± 1.0 | 3.8 ± 0.7 | 6.9 ± 1.3 | 5.3 ± 0.8 | 3.6 ± 0.5 |
| 16 | 9.0 ± 1.0 | 6.1 ± 0.9 | 4.9 ± 0.7 | 10.4 ± 1.5 | 6.4 ± 0.9 | 5.3 ± 0.7 |
| 20 | 10.7 ± 1.2 | 6.5 ± 0.8 | 5.3 ± 0.7 | 11.4 ± 1.7 | 7.5 ± 1.0 | 5.7 ± 0.5 |
| 24 | 12.3 ± 1.5†† | 7.5 ± 0.9†† | 6.0 ± 0.7†† | 12.7 ± 1.7†† | 8.5 ± 1.0†† | 6.8 ± 0.8†† |
| Range (Hz) | 6.1 ± 0.5†† | 2.9 ± 0.8 | 2.2 ± 0.3 | 5.8 ± 0.6†† | 3.4 ± 0.4 | 3.0 ± 0.5 |
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Mean firing rates (Hz) of cortical neurons in response to M/T population current stimuli. These rates are shown for all combinations of simulated respiration frequency (2 or 8 Hz rhythms), presynaptic M/T firing rate (FR, 12–24 Hz), and synaptic plasticity (F, facilitation dominant; FD, facilitating-depressing; D, depression dominant).
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↵Mean cortical firing rates increased significantly for comparisons between presynaptic rates of 12 and 24 Hz (††p < 0.01, paired t test) but not for discrete comparisons (i.e., 12 vs 16, 16 vs 20, 20 vs 24). Furthermore, the range of mean cortical firing rates that represent the 12–24 Hz change in presynaptic rate was significantly greater for F synapses (††p < 0.01, paired t test) than the FD or D synapses.