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Article: Transient neurophysiological changes in CA3 neurons and dentate granule cells after severe forebrain ischemia in vivo.

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Gao TM; Howard EM; Xu ZC
J. Neurophysiol., 1998


Table 1.

Electrophysiological properties of CA3 neurons after reperfusion

RMP, mV Spike Spike Width, ms Rin, MΩ Time Spontaneous Firing, Hz
Height, mV Constant, ms
Before ischemia −66 ± 5.5 75 ± 9.7 0.76 ± 0.15 26.6 ± 8.5 15.2 ± 7.6 1.28 ± 1.38
(19) (22) (22) (17) (17) (10)
∼6 h after reperfusion −61 ± 6.1* 78 ± 8.7 0.89 ± 0.26* 20.7 ± 5.0 10.9 ± 4.8 0.83 ± 1.29
(11) (14) (14) (9) (9) (10)
∼21 h after reperfusion −64 ± 4.6 77 ± 5.8 0.76 ± 0.07 23.8 ± 1.7 13.2 ± 4.5 0.65 ± 1.31
(11) (10) (10) (9) (9) (10)
∼29 h after reperfusion −64 ± 3.2 75 ± 7.9 0.73 ± 0.08 29.0 ± 12.8 17.3 ± 7.4 2.13 ± 3.56
(12) (15) (15) (10) (10) (8)
∼43 h after reperfusion −66 ± 4.6 76 ± 10.4 0.77 ± 0.11 29.3 ± 10.9 14.3 ± 8.5 1.11 ± 1.82
(15) (17) (17) (16) (16) (10)
7 d after reperfusion −65 ± 2.5 76 ± 10.8 0.82 ± 0.09 32.6 ± 7.8 12.1 ± 2.3 1.34 ± 1.01
(10) (10) (10) (8) (8) (7)
  • Values are means ± SD with number of neurons in parentheses. Spike height is measured from the resting membrane potential. Spike width is measured at one-half of the peak amplitude of the action potential. Input resistance (R in) is derived from the linear portion of the current-voltage curve (0 to −0.5 nA). Time constant is derived from transients of hyperpolarizing pulse (−0.3 nA, 200 ms). RMP, resting membrane potential.

  • * P < 0.01, analysis of variance.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -66.0 ± 5.5 (17) -66.0 (mV) Data Table
Hippocampus CA3 pyramidal cell spike amplitude from resting 75.0 ± 9.7 (17) 75.0 (mV) Data Table
Hippocampus CA3 pyramidal cell spike half-width (ms) 0.76 ± 0.15 (17) 0.76 (ms) Data Table
Hippocampus CA3 pyramidal cell input resistance (MΩ) 26.6 ± 8.5 (17) 26.6 (MΩ) Data Table
Hippocampus CA3 pyramidal cell membrane time constant 15.2 ± 7.6 (17) 15.2 (ms) Data Table
Hippocampus CA3 pyramidal cell spontaneous firing rate (Hz) 1.28 ± 1.38 (17) 1.28 (Hz) Data Table