Article: Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.

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Levine MS; Altemus KL; Cepeda C; Cromwell HC; Crawford C; Ariano MA; Drago J; Sibley DR; Westphal H
J. Neurosci., 1996

Table 1.

Basic membrane and DPSP properties

A. Basic membrane properties

	Resting membrane potential (mV)	Action potential		Rheobase (nA)	Input resistance (MΩ)
	Resting membrane potential (mV)	Amplitude (mV)	Duration (msec)	Rheobase (nA)	Standard ACSF	Mg²⁺-free ACSF + CNQX
Control	−73.6 ± 1.2^1_a	72.4 ± 1.1	0.90 ± 0.03	0.58 ± 0.05	30.5 ± 1.4	35.9 ± 3.3^1_b
Mutant	−73.6 ± 1.0	71.4 ± 0.9	0.98 ± 0.04	0.54 ± 0.06	34.6 ± 2.3	47.1 ± 4.1

↵F1_a Mean ± SE. Values for resting membrane potential, action potential parameters, and rheobase were derived from 49 cells from controls and 55 cells from mutants. Data from cells bathed in standard ACSF and Mg²⁺-free ACSF + CNQX were pooled, because there were no significant differences between groups. Input resistance measures in standard ACSF were obtained from 16 control and 17 mutant cells and in Mg²⁺-free ACSF + CNQX from 13 control and 11 mutant cells.
↵F1_b Difference between means from controls and mutants is statistically significant (t = 2.15, df = 22,p = 0.0431).

Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neostriatum medium spiny neuron	resting membrane potential (mV)	-73.6 ± 1.21 (29)	-73.6 (mV)	Data Table
Neostriatum medium spiny neuron	spike amplitude (mV)	72.4 ± 1.1 (29)	72.4 (mV)	Data Table
Neostriatum medium spiny neuron	spike half-width (msec)	0.9 ± 0.03 (29)	0.9 (ms)	Data Table
Neostriatum medium spiny neuron	rheobase (nA)	0.58 ± 0.05 (29)	580.0 (pA)	Data Table
Neostriatum medium spiny neuron	input resistance	30.5 ± 1.4 (29)	30.5 (MΩ)	Data Table
Neostriatum medium spiny neuron	input resistance	35.9 ± 3.31 (29)	35.9 (MΩ)	Data Table