Article: Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Klink R; de Kerchove d'Exaerde A; Zoli M; Changeux JP
J. Neurosci., 2001

Table 1.

Electrophysiological parameters of DA and Gaba neurons in the SN and VTA

	Spike threshold	fAHP	Spike width	I_h Sag	Firing frequency
DA (n = 55) 24/9/22	−34 ± 1 mV	20 ± 1 mV	2.62 ± 0.08 msec	39 ± 3%	2.4 ± 0.3 Hz (n = 24)
Gaba (n = 24) 3/11/10	−42 ± 1 mV	13 ± 1 mV	1.32 ± 0.09 msec	9 ± 2%	17.2 ± 3.1 Hz (n = 11)

Number of neurons in each of the SNc/SNr/VTA is indicated below neuron class label. All quantified parameters were significantly different (p < 0.001) between DA and Gaba neurons. Fast afterhyperpolarization (fAHP) was measured from threshold; spike width was measured at threshold; I _h sag quantifies the time-dependent relaxation in the voltage response to hyperpolarizing current steps, indicative of I _hcurrent activation; firing frequency was evaluated at the resting membrane potential in spontaneously active neurons.

Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Other	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area GABAergic neurons	spike half-width	1.32 ± 0.09 (24)	1.32 (ms)	Data Table
Other	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area GABAergic neurons	sag ratio	9.0 ± 2.0 (24)	0.09 (ratio)	Data Table
Other	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area GABAergic neurons	firing frequency	17.2 ± 3.1 (24)	17.2 (Hz)	Data Table
Substantia nigra pars compacta dopaminergic cell	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area dopaminergic neurons	spike threshold	-34.0 ± 1.0 (55)	-34.0 (mV)	Data Table
Substantia nigra pars compacta dopaminergic cell	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area dopaminergic neurons	fast AHP amplitude	20.0 ± 1.0 (55)	20.0 (mV)	Data Table
Substantia nigra pars compacta dopaminergic cell	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area dopaminergic neurons	spike half-width	2.62 ± 0.08 (55)	2.62 (ms)	Data Table
Substantia nigra pars compacta dopaminergic cell	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area dopaminergic neurons	sag ratio	39.0 ± 3.0 (55)	0.39 (ratio)	Data Table
Substantia nigra pars compacta dopaminergic cell	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area dopaminergic neurons	firing frequency	2.4 ± 0.3 (55)	2.4 (Hz)	Data Table
Other	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area GABAergic neurons	spike threshold	-42.0 ± 1.0 (24)	-42.0 (mV)	Data Table
Other	Substantia Nigra Compacta, Substantia Nigra Reticula and Ventral Tegmental Area GABAergic neurons	fast AHP amplitude	13.0 ± 1.0 (24)	13.0 (mV)	Data Table