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Article: Electrophysiological Abnormalities in Both Axotomized and Nonaxotomized Pyramidal Neurons following Mild Traumatic Brain Injury.

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Greer JE; Povlishock JT; Jacobs KM
J. Neurosci., 2012


Table 1.

Intrinsic properties of injured and control YFP-labeled pyramidal neurons

Measure Control Axotomized, 1 d Intact, 1 d Axotomized, 2 d Intact, 2 d
RMP (mV) −60.1 ± 0.3 (23) −61.1 ± 0.8 (11) −59.7 ± 0.3 (8) −60.4 ± 0.7 (7) −59.7 ± 0.4 (6)
Overshoot (mV) 50.4 ± 1.7 57.3 ± 0.9 58.2 ± 2.4 56.9 ± 1.5 48.7 ± 4.2
τ (ms) 17.1 ± 1.5 15.1 ± 1.1 15.6 ± 3.0 15.9 ± 1.5 15.1 ± 1.2
Rin (MΩ) 87.2 ± 7.2 87.4 ± 16.5 106.9 ± 22.2 106.5 ± 6.8 119.6 ± 6.3
Calculations for RS cells only
    RMP (mV) −60.2 ± 0.4 (15) −61.2 ± 0.9 (9) −59.7 ± 0.3 (7) −60.3 ± 0.8 (6) −59.7 ± 0.4 (6)
    τ (ms) 15.7 ± 0.9 15.6 ± 1.2 16.6 ± 3.3 15.4 ± 1.7 15.1 ± 1.2
    Rin (MΩ) 86.4 ± 8.6 87.5 ± 20.4 116.5 ± 23.2 106.6 ± 8.1 119.6 ± 6.3
    AP rise time(ms) 0.25 ± 0.02 0.28 ± 0.04 0.26 ± 0.02 0.29 ± 0.05 0.26 ± 0.02
    AP threshold (mV) −37.6 ± 0.9 −38.2 ± 0.8 −37.3 ± 0.7 −33.1 ± 1.5 −35.8 ± 1.4

  • Results reported as mean ± SEM (n cells).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex membrane time constant (ms) 17.1 ± 1.5 17.1 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex resting membrane potential (mV) -60.1 ± 0.3 (23) -60.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex input resistance (MΩ) 87.2 ± 7.2 87.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex resting membrane potential (mV) -60.2 ± 0.4 (15) -60.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex membrane time constant (ms) 15.7 ± 0.9 15.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex input resistance (MΩ) 86.4 ± 8.6 86.4 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex spike rise time (ms) 0.25 ± 0.02 0.25 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex spike threshold (mV) -37.6 ± 0.9 -37.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Regular spiking, Thy1-expressing layer V pyramidal neurons of somatosensory cortex spike peak (mV) 50.4 ± 1.7 50.4 (mV) Data Table