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Article: Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life.

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Schridde U; Strauss U; Bräuer AU; van Luijtelaar G
Eur. J. Neurosci., 2006


Table 2.   Common voltage-clamp and Ih properties of layer 5 pyramidal neurons from somatosensory cortex of WAG/Rij rats raised under different rearing conditions
 Control(n)MD(n)NH(n)
  1. Data presented as the mean ± SEM (n, number of cells), *P < 0.05 when compared to slope-factors in the same group without cAMP.

C (pF)109.0 ± 13.517101.3 ± 5.422122.0 ± 10.019
Vh-reversal (mV)−45.0 ± 1.55−41.2 ± 1.38−41.3 ± 1.96
V1/2 (mV)−85.3 ± 2.39−86.4 ± 2.012−86.1 ± 1.110
Slope-factor (k)11.1 ± 0.8910.7 ± 0.61212.4 ± 0.410
V1/2– 100 µm cAMP (mV)−82.6 ± 1.18−85.6 ± 1.310−84.8 ± 0.99
Slope-factor (k) – 100 µm cAMP8.9 ± 0.8*89.4 ± 0.2*109.6 ± 0.4*9

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