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Article: Excitatory effects of low-level lead exposure on action potential firing of pyramidal neurons in CA1 region of rat hippocampal slices.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Yan D; Xiao C; Ma FL; Wang L; Luo YY; Liu J; Wang HL; Chen JT; Ruan DY
J. Neurosci. Res., 2008


Table I. Effects of Lead on the Parameters of Single Action Potential*
 0.5 μM pb (n = 12)0.5 μM pb (n = 13)
ControlTestControlTest
  • *

    Control and test: action potential waveform induced by threshold stimuli before and 20 min after concentrations of lead containing ACSF perfusion.

Input resistance (MΩ)291 ± 53299 ± 58206 ± 22263 ± 45
Voltage threshold (mV)−47.7 ± 0.8−48.7 ± 0.6−47.8 ± 0.9−47.1 ± 1.1
Amplitude (mV)88.0 ± 4.384.8 ± 4.883.6 ± 5.882.6 ± 4.4
Rise time (m sec)0.70 ± 0.030.73 ± 0.040.71 ± 0.050.66 ± 0.04
Duration (m sec)2.04 ± 0.082.02 ± 0.102.23 ± 0.042.10 ± 0.04

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike threshold (mV) -47.8 ± 0.9 (13) -47.8 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 88.0 ± 4.3 (12) 88.0 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 83.6 ± 5.8 (13) 83.6 (mV) Data Table
Hippocampus CA1 pyramidal cell spike rise time (m sec) 0.7 ± 0.03 (12) 0.7 (ms) Data Table
Hippocampus CA1 pyramidal cell spike rise time (m sec) 0.71 ± 0.05 (13) 0.71 (ms) Data Table
Hippocampus CA1 pyramidal cell spike width (m sec) 2.04 ± 0.08 (12) 2.04 (ms) Data Table
Hippocampus CA1 pyramidal cell spike width (m sec) 2.23 ± 0.04 (13) 2.23 (ms) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 291.0 ± 53.0 (12) 291.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 206.0 ± 22.0 (13) 206.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -47.7 ± 0.8 (12) -47.7 (mV) Data Table