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Article: Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.

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Gantz SC; Ford CP; Neve KA; Williams JT
J. Neurosci., 2011


Table 1.

Characteristics of dopamine neurons in wild type and Mecp2+/− females

Age Mecp2+/+ Mecp2+/−
Young (26–30 d) Adult (250–812 d) Young (27–30 d) Adult (270–519 d)
Mecp2 + + + +
Capacitance (pF) 31.7 ± 1.0 (41) 24.7 ± 0.5° (127) 31.9 ± 1.3 (26) 26.4 ± 1.8*(20) 25.1 ± 1.1° (32) 18.9 ± 1.5*° (18)
Resistance (MΩ/pF) 6.7 ± 0.3 (41) 9.9 ± 0.5° (82) 8.8 ± 0.8 (26) 11.5 ± 1.1* (20) 9.2 ± 0.7 (32) 18.5 ± 2.0*° (18)
Number of processes 13.3 ± 0.5 (25) 10.4 ± 0.5° (25) 13.0 ± 0.6 (23) 10.2 ± 0.6* (19) 10.4 ± 0.4° (30) 9.6 ± 0.5 (16)
Length of processes (μm) 110.5 ± 6.0 (25) 108.7 ± 4.8 (25) 103.8 ± 6.2 (23) 101.3 ± 5.3 (19) 104.0 ± 5.5 (30) 81.9 ± 5.8*° (16)
Total length of processes (μm) 1453 ± 83 (25) 1132 ± 84° (25) 1353 ± 99 (23) 1012 ± 64* (19) 1074 ± 61° (30) 792 ± 78*° (16)
Dopamine current density (pA/pF) 8.1 ± 0.4 (39) 7.7 ± 0.3 (111) 7.8 ± 0.4 (26) 7.0 ± 0.5 (19) 7.0 ± 0.5 (29) 5.0 ± 0.7*° (17)
  • Boldface designates statistical significance. The number of cells is shown in parentheses.

  • *Statistical significance compared to age-matched wild type.

  • Statistical significance compared to age-matched HET+.

  • °Statistical significance compared to young age within genotype.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Substantia nigra pars compacta dopaminergic cell cell capacitance (pF) 31.7 ± 1.0 31.7 (pF) Data Table
Substantia nigra pars compacta dopaminergic cell cell capacitance (pF) 24.7 ± 0.5 24.7 (pF) Data Table