Article: Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Gantz SC; Ford CP; Neve KA; Williams JT J. Neurosci., 2011
Region | Age | Kd (pm) | Bmax (fmol/mg protein) | n | |||
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Mecp2+/+ | Mecp2+/− | Mecp2+/+ | Mecp2+/− | Mecp2+/+ | Mecp2+/− | ||
Midbrain | Young (26–37 d) | 18 (16–20) | 29 (19–44) | 58.2 ± 6.9 | 58.8 ± 10.0 | 7 | 3 |
Adult (169–446 d) | 24 (23–26) | 23 (19–27) | 44.7 ± 2.0 | 43.8 ± 4.6 | 7 | 6 | |
Striatum | Young (26–37 d) | 16 (13–19) | 18 (13–25) | 709.7 ± 48.9 | 737.9 ± 12.8 | 4 | 3 |
Adult (169–446 d) | 17 (15–19) | 17 (15–20) | 569.6 ± 17.9° | 591.6 ± 45.2° | 7 | 6 |
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The affinity (Kd) and density (Bmax) of D2 receptors were determined by saturation analysis of binding of [3H]YM-09151-2 in membranes prepared from three to seven brains as described under Materials and Methods. Kd values are the geometric means, followed by the limits defined by the SEM in parentheses. Bmax values represent the mean ± SEM; the symbol ° designates statistical significance compared to young age within genotype. Boldface designates statistical significance.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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