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Article: Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.

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Hourez R; Servais L; Orduz D; Gall D; Millard I; de Kerchove d'Exaerde A; Cheron G; Orr HT; Pandolfo M; Schiffmann SN
J. Neurosci., 2011


Table 1.

Passive and active parameters

Unit WT (no. of cells = 18) SCA1 (no. of cells = 38) t test
Mean SEM Mean SEM
Passive parameters
    Access resistance 23.65 1.11 22.86 2.85 0.89 NS
    Apparent membrane capacitance pF 334.14 25.17 349.32 18.74 0.63 NS
    Membrane input resistance 0.14 0.02 0.16 0.02 0.56 NS
    Resting membrane potential mV −58.55 1.36 −57.39 1.00 0.51 NS
Action potential analysis (injected current = 0 pA)
    Afterhyperpolarization mV −63.38 1.09 −61.54 0.95 0.25 NS
    Frequency Hz 42.27 3.22 29.11 2.06 0.00 **
    Half-width ms 0.27 0.01 0.25 0.01 0.17 NS
    Ascending slope V/s 314.31 32.70 361.00 17.02 0.17 NS
    Descending slope V/s −226.84 27.57 −235.53 12.79 0.74 NS
Action potential analysis (excitability recordings)
    Afterhyperpolarization mV −68.18 1.53 −65.40 0.95 0.13 NS
    Half-width ms 0.23 0.01 0.22 0.01 0.49 NS
    Ascending slope V/s 368.52 26.60 420.36 16.06 0.10 NS
    Descending slope V/s −277.09 25.77 −293.49 14.98 0.56 NS
    Excitability slope Hz/pA 0.23 0.02 0.21 0.01 0.13 NS
  • Passive parameters and action potential analysis from patch-clamp recordings of Purkinje cells from 2- to 3-week-old WT and SCA1 mice.

  • NS, No significant difference (p > 0.05); **p < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Purkinje cell spike half-width 0.23 (18) 0.23 (ms) Data Table
Cerebellum Purkinje cell access resistance 23.65 (18) 23.65 (MΩ) Data Table
Cerebellum Purkinje cell spike max rise slope 368.52 (18) 368.52 (mV/ms) Data Table
Cerebellum Purkinje cell spike max decay slope -277.09 (18) 277.09 (mV/ms) Data Table
Cerebellum Purkinje cell FI slope 0.23 (18) 0.23 (Hz/nA) Data Table
Cerebellum Purkinje cell cell capacitance 334.14 (18) 334.14 (pF) Data Table
Cerebellum Purkinje cell input resistance (GΩ) 0.14 (18) 140.0 (MΩ) Data Table
Cerebellum Purkinje cell resting membrane potential -58.55 (18) -58.55 (mV) Data Table
Cerebellum Purkinje cell AHP voltage -68.18 (18) -68.18 (mV) Data Table