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Article: Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.

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Hourez R; Servais L; Orduz D; Gall D; Millard I; de Kerchove d'Exaerde A; Cheron G; Orr HT; Pandolfo M; Schiffmann SN
J. Neurosci., 2011


Table 2.

In vivo recordings

Parameters Unit WT (no. of cells = 35) SCA1 (no. of cells = 35) t test
Mean SEM Mean SEM
Simple spike frequency Hz 71.29 5.70 28.24 2.38 1.15E-08 ***
CS frequency Hz 1.47 0.08 1.25 0.08 0.06 NS
CS duration ms 9.17 0.27 11.38 0.42 0.0001 ***
Pause duration after CS ms 12.94 0.57 27.42 1.81 6.42E-09 ***
Simple spike rythmicity index 0.06 0.01 0.02 0.00 0.004 **

  • In vivo recordings parameters of Purkinje cells from 4- to 5-week-old WT and SCA1 mice. CS, Complex spike.

  • ↵NS, No significant difference (p > 0.05); **p < 0.01; ***p < 0.001.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source