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Article: Lateral hypothalamic GAD65 neurons are spontaneously firing and distinct from orexin- and melanin-concentrating hormone neurons.

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Karnani MM; Szabó G; Erdélyi F; Burdakov D
J. Physiol. (Lond.), 2013


Table 1.  Summary of electrophysiological parameters for LH GAD65-GFP neurons
 FSLSLTSRS 
  1. Values are means ± SEM (n). Statistical testing shown as > = P < 0.05 and >> = P < 0.01. *LTS cells without V(IT). Abbreviations: AP, action potential; RMP, resting membrane potential.

Spike ratio2.6 ± 0.5  (20)0.1 ± 0.0  (15)3.1 ± 0.2  (33)1.1 ± 0.0  (71)LTS, FS>>RS>>LS
Maximum firing frequency (Hz)257.5 ± 11.6  (20)67.2 ± 7.7  (15)135.7 ± 7.8  (33)105.2 ± 5.2  (71)FS>>LTS>RS>>LS
Steady-state firing frequency (Hz)103.6 ± 9.2  (20)49.4 ± 3.9  (15)50.6 ± 4.4  (32)50.7 ± 3.1  (71)FS>>LTS, RS, LS
Adaptation ratio0.39 ± 0.03  (20)0.79 ± 0.07  (15)0.39 ± 0.03  (33)0.50 ± 0.02  (71)LS>>RS>FS, LTS
AP threshold (mV)−40.4 ± 0.7  (20)−36.8 ± 0.9  (15)−38.8 ± 0.5  (33)−38.1 ± 0.6  (71)LS>FS
AP half-width (ms)0.41 ± 0.02  (20)0.80 ± 0.08  (15)0.60 ± 0.03  (33)0.64 ± 0.03  (71)LS>>RS, LTS>>FS
AP afterhyperpolarization (mV)−25.1 ± 0.8  (20)−26.6 ± 1.4  (15)−23.4 ± 0.8  (33)−25.7 ± 0.6  (71)LS>LTS
AP peak amplitude (mV)73.8 ± 2.3  (20)59.4 ± 3.7  (15)63.0 ± 1.8  (33)59.2 ± 1.8  (71)FS>>LS, LTS, RS
AP max. rise slope (mV ms−1)334.2 ± 18.1  (20)195.1 ± 19.8  (15)226.9 ± 16.9  (33)220.4 ± 11.3  (71)FS>>LS, LTS, RS
AP 10–90% decay time (ms)0.23 ± 0.02  (20)0.69 ± 0.09  (15)0.44 ± 0.03  (33)0.47 ± 0.03  (71)LS>>LTS, RS>>FS
Firing frequency at rest (Hz)8.9 ± 1.8  (18)7.9 ± 1.6  (13)8.1 ± 1.1  (30)9.5 ± 0.8  (63) 
Input resistance (MΩ)463 ± 89  (15)628 ± 94  (13)416 ± 39  (29)646 ± 54  (58)RS>LTS
RMP (mV)−53.7 ± 3.0  (15)−47.6 ± 1.7  (10)−51.7 ± 1.9  (30)−48.3 ± 1.7  (54) 
Membrane time constant (ms)28.5 ± 1.6  (12)24.2 ± 3.6  (14)25.0 ± 2.6  (18)25.0 ± 4.2  (15) 
Membrane capacitance (pF)16.9 ± 1.3  (17)17.8 ± 1.5  (14)16.3 ± 0.8  (34)15.5 ± 0.6  (68) 
A-like current amplitude (pA)160 ± 45  (14)1575 ± 296  (12)217 ± 40  (29)472 ± 49  (61)LS>>RS>FS; LS>>LTS
I h-mediated depolarization (mV)6.6 ± 0.9  (16)5.6 ± 1.1  (13)9.7 ± 1.3  (15)*3.0 ± 0.9  (21)LTS*>RS, LS
Number of cells with V(IT)4  (16)0  (13)10  (26)9  (65) 

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Lateral hypothalamus GAD65-GFP late spiking neurons maximum firing rate (Hz) 67.2 ± 7.7 (15) 67.2 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons maximum firing rate (Hz) 135.7 ± 7.8 (33) 135.7 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons maximum firing rate (Hz) 105.2 ± 5.2 (71) 105.2 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons firing frequency (Hz) 103.6 ± 9.2 (20) 103.6 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons firing frequency (Hz) 49.4 ± 3.9 (15) 49.4 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons firing frequency (Hz) 50.6 ± 4.4 (32) 50.6 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons firing frequency (Hz) 50.7 ± 3.1 (71) 50.7 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons adaptation ratio 0.39 ± 0.03 (20) 0.39 (ratio) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons adaptation ratio 0.79 ± 0.07 (15) 0.79 (ratio) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons adaptation ratio 0.39 ± 0.03 (33) 0.39 (ratio) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons adaptation ratio 0.5 ± 0.02 (71) 0.5 (ratio) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons spike threshold (mV) -40.4 ± 0.7 (20) -40.4 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons spike threshold (mV) -36.8 ± 0.9 (15) -36.8 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons spike threshold (mV) -38.8 ± 0.5 (33) -38.8 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons spike threshold (mV) -38.1 ± 0.6 (71) -38.1 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons spike half-width (ms) 0.41 ± 0.02 (20) 0.41 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons spike half-width (ms) 0.8 ± 0.08 (15) 0.8 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons spike half-width (ms) 0.6 ± 0.03 (33) 0.6 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons spike half-width (ms) 0.64 ± 0.03 (71) 0.64 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons AHP amplitude (mV) -25.1 ± 0.8 (20) 25.1 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons AHP amplitude (mV) -26.6 ± 1.4 (15) 26.6 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons AHP amplitude (mV) -23.4 ± 0.8 (33) 23.4 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons AHP amplitude (mV) -25.7 ± 0.6 (71) 25.7 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons spike amplitude (mV) 73.8 ± 2.3 (20) 73.8 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons spike amplitude (mV) 59.4 ± 3.7 (15) 59.4 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons spike amplitude (mV) 63.0 ± 1.8 (33) 63.0 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons spike amplitude (mV) 59.2 ± 1.8 (71) 59.2 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons spike max rise slope 334.2 ± 18.1 (20) 334.2 (mV/ms) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons spike max rise slope 195.1 ± 19.8 (15) 195.1 (mV/ms) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons spike max rise slope 226.9 ± 16.9 (33) 226.9 (mV/ms) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons spike max rise slope 220.4 ± 11.3 (71) 220.4 (mV/ms) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons spike decay time (ms) 0.23 ± 0.02 (20) 0.23 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons spike decay time (ms) 0.69 ± 0.09 (15) 0.69 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons spike decay time (ms) 0.44 ± 0.03 (33) 0.44 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons spike decay time (ms) 0.47 ± 0.03 (71) 0.47 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons spontaneous firing rate (Hz) 8.9 ± 1.8 (18) 8.9 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons spontaneous firing rate (Hz) 7.9 ± 1.6 (13) 7.9 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons spontaneous firing rate (Hz) 8.1 ± 1.1 (30) 8.1 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons spontaneous firing rate (Hz) 9.5 ± 0.8 (63) 9.5 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons input resistance (MΩ) 463.0 ± 89.0 (15) 463.0 (MΩ) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons input resistance (MΩ) 628.0 ± 94.0 (13) 628.0 (MΩ) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons input resistance (MΩ) 416.0 ± 39.0 (29) 416.0 (MΩ) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons input resistance (MΩ) 646.0 ± 54.0 (58) 646.0 (MΩ) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons resting membrane potential (mV) -53.7 ± 3.0 (15) -53.7 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons resting membrane potential (mV) -47.6 ± 1.7 (10) -47.6 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons resting membrane potential (mV) -51.7 ± 1.9 (30) -51.7 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons resting membrane potential (mV) -48.3 ± 1.7 (54) -48.3 (mV) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons membrane time constant (ms) 28.5 ± 1.6 (12) 28.5 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons membrane time constant (ms) 24.2 ± 3.6 (14) 24.2 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons membrane time constant (ms) 25.0 ± 2.6 (18) 25.0 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons membrane time constant (ms) 25.0 ± 4.2 (15) 25.0 (ms) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons cell capacitance (pF) 16.9 ± 1.3 (17) 16.9 (pF) Data Table
Other Lateral hypothalamus GAD65-GFP late spiking neurons cell capacitance (pF) 17.8 ± 1.5 (14) 17.8 (pF) Data Table
Other Lateral hypothalamus GAD65-GFP low-threshold spiking neurons cell capacitance (pF) 16.3 ± 0.8 (34) 16.3 (pF) Data Table
Other Lateral hypothalamus GAD65-GFP fast spiking neurons maximum firing rate (Hz) 257.5 ± 11.6 (20) 257.5 (Hz) Data Table
Other Lateral hypothalamus GAD65-GFP regular spiking neurons cell capacitance (pF) 15.5 ± 0.6 (68) 15.5 (pF) Data Table