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Article: Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Noaín D; Avale ME; Wedemeyer C; Calvo D; Peper M; Rubinstein M
Eur. J. Neurosci., 2006


Table 1.   Electrophysiological properties of pyramidal EGFP and non-EGFP-expressing neurons in the medial prefrontal cortex (lamina V) of Drd4-EGFP transgenic mice
 Resting membrane potential (mV)Membrane input resistance (MΩ) AP threshold (mV) AP amplitude (mV)AP halfwidth (ms)
  1. Numerical values are expressed as mean ± SEM. Parameters were compared using Student's t-test for unpaired samples.

EGFP-positive (n = 9)−68.4 ± 1.3149.3 ± 13.7−44.9 ± 2.692.4 ± 2.82.9 ± 0.3
EGFP-negative (n = 8)−65.9 ± 0.7175.9 ± 27.4−43.7 ± 0.693.1 ± 2.02.3 ± 0.3

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V non-Drd4-expressing Pyramidal Neuron input resistance (MΩ) 175.9 ± 27.4 (8) 175.9 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V non-Drd4-expressing Pyramidal Neuron spike threshold (mV) -43.7 ± 0.6 (8) -43.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V non-Drd4-expressing Pyramidal Neuron spike amplitude (mV) 93.1 ± 2.0 (8) 93.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V non-Drd4-expressing Pyramidal Neuron spike half-width (ms) 2.3 ± 0.3 (8) 2.3 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V Drd4-expressing Pyramidal Neuron resting membrane potential (mV) -68.4 ± 1.3 (9) -68.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V Drd4-expressing Pyramidal Neuron input resistance (MΩ) 149.3 ± 13.7 (9) 149.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V Drd4-expressing Pyramidal Neuron spike threshold (mV) -44.9 ± 2.6 (9) -44.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V Drd4-expressing Pyramidal Neuron spike amplitude (mV) 92.4 ± 2.8 (9) 92.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V Drd4-expressing Pyramidal Neuron spike half-width (ms) 2.9 ± 0.3 (9) 2.9 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Medial Prefrontal Cortex Layer V non-Drd4-expressing Pyramidal Neuron resting membrane potential (mV) -65.9 ± 0.7 (8) -65.9 (mV) Data Table