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Article: Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats.

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Rüschenschmidt C; Koch PG; Brüstle O; Beck H
Epilepsia, 2005


Table 1. Passive membrane properties and action potential parameters of embryonic stem cell–derived neurons incorporated into the hippocampus of control and pilocarpine-treated rats in comparison with those of endogenous granule cells
 Membrane capacitance (pF)Input resistance (GΩ)Threshold (mV)Amplitude (mV)Half-width (ms)
Control47.6 ± 3.61.46 ± 0.37−49.8±1.652.6 ± 2.42.29 ± 0.19
(n = 13)(n = 10)(n = 9)(n = 9)(n = 9)
Pilocarpine-treated40.0 ± 4.81.51 ± 0.38−51.1 ± 2.548.4 ± 2.92.74 ± 0.19
(n = 13)(n = 10) (n = 10) (n = 10) (n = 10)
Endogenous granule cells control (n = 4)120.7 ± 10.50.248 ± 0.039–57.0 ± 3.9107.0 ± 3.11.20 ± 0.02
Endogenous granule cells pilocarpine-treated (n = 3)130.6 ± 19.00.308 ± 0.064–55.3 ± 1.9104.3 ± 2.41.16 ± 0.03

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus granule cell cell capacitance (pF) 120.7 ± 10.5 (4) 120.7 (pF) Data Table
Dentate gyrus granule cell input resistance (GΩ) 0.248 ± 0.039 (4) 248.0 (MΩ) Data Table
Dentate gyrus granule cell spike threshold (mV) -57.0 ± 3.9 (4) -57.0 (mV) Data Table
Dentate gyrus granule cell spike amplitude (mV) 107.0 ± 3.1 (4) 107.0 (mV) Data Table
Dentate gyrus granule cell spike half-width (ms) 1.2 ± 0.02 (4) 1.2 (ms) Data Table