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Article: Seizure, neuron loss, and mossy fiber sprouting in herpes simplex virus type 1-infected organotypic hippocampal cultures.

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Chen SF; Huang CC; Wu HM; Chen SH; Liang YC; Hsu KS
Epilepsia, 2004


Table 1. Electrophysiological properties of hippocampal CA3 pyramidal neurons before and after HSV-1 infection in organotypic slice cultures
ParametersControl Regular3 DPI (Group I)3 DPI (Group II)3 DPI (Group III)
RegularGrade IGrade IIRegularGrade IGrade IIRegularGrade II
  1. RMP, resting membrane potential; Vmax, maximal rate of increase of the action potential; fAHP amplitude, the peak amplitude of fast afterhyperpolarization that followed the end of depolarizing current pulses (300 ms, 1.0 nA); Number, number of recording neurons. Data are presented as mean ± SEM.

  2. ap < 0.05, unpaired Student's t test.

RMP (mV)−71.8 ± 1.4 −69.9 ± 2.5 −61.7 ± 2.2a −60.8 ± 1.7a −72.3 ± 1.9 −60.8 ± 2.3a−62.9 ± 2.7a−71.2 ± 2.3 −60.8 ± 2.3a−62.9 ± 2.7a
Input resistance (MΩ)70.4 ± 3.171.8 ± 2.3 83.7 ± 2.3a  83.5 ± 2.8a72.8 ± 1.5 86.7 ± 2.1a 79.5 ± 2.9a74.8 ± 2.5 82.3 ± 2.4a 84.6 ± 2.7a
Spike threshold (mV)−56.2 ± 1.7 −56.8 ± 1.4 −55.8 ± 1.4 −54.2 ± 1.6 −55.8 ± 2.4 −54.8 ± 1.3 −56.2 ± 1.2 −56.2 ± 2.3 −55.4 ± 1.8 −53.8 ± 2.7 
Spike amplitude (mV)81.3 ± 1.681.8 ± 1.379.6 ± 2.178.9 ± 1.980.9 ± 1.9 81.6 ± 1.6 80.9 ± 1.3 82.1 ± 1.8 82.5 ± 1.9  82.1 ± 1.8 
Vmax (mV/ms)236.4 ± 14.7231.8 ± 12.4224.3 ± 12.6233.6 ± 16.8228.8 ± 16.3 221.3 ± 15.6225.6 ± 9.2 227.4 ± 18.3 225.2 ± 16.6 219.6 ± 14.2
fAHP amplitude (mV)10.7 ± 2.1 9.8 ± 2.8 5.2 ± 2.1a 4.2 ± 1.9a10.2 ± 2.6  5.3 ± 2.4a  4.9 ± 1.6a11.2 ± 2.3  5.8 ± 2.3a  5.2 ± 2.4a
Number173107782483

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell input resistance (MΩ) 70.4 ± 3.1 (17) 70.4 (MΩ) Data Table
Hippocampus CA3 pyramidal cell spike threshold (mV) -56.2 ± 1.7 (17) -56.2 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -71.8 ± 1.4 (17) -71.8 (mV) Data Table
Hippocampus CA3 pyramidal cell spike amplitude (mV) 81.3 ± 1.6 (17) 81.3 (mV) Data Table
Hippocampus CA3 pyramidal cell spike max rise slope (mV/ms) 236.4 ± 14.7 (17) 236.4 (mV/ms) Data Table
Hippocampus CA3 pyramidal cell fast AHP amplitude (mV) 10.7 ± 2.1 (17) 10.7 (mV) Data Table