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Article: Maturation of "neocortex isole" in vivo in mice.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Zhou L; Gall D; Qu Y; Prigogine C; Cheron G; Tissir F; Schiffmann SN; Goffinet AM
J. Neurosci., 2010


Table 3.

Excitability of pyramidal neurons in slices

Parameters WT (n = 20) Celsr3 Dlx (n = 19)
Vresting (mV) −71.2 ± 1.6 −70.3 ± 0.8
Rin (MΩ) 363.4 ± 35.3 399.8 ± 37.1
Cm (pF) 105.5 ± 7.3 100.6 ± 7.3
Threshold current (pA) 90.9 ± 9.1 117.9 ± 10.0*
Threshold voltage (mV) −40.7 ± 1.6 −32.0 ± 1.4**
Latency of 1st AP (s) 0.08 ± 0.02 0.09 ± 0.02
AHP (mV) −54.3 ± 1.9 −43.2 ± 1.5**
Half-width (ms) 1.58 ± 0.17 2.47 ± 0.23**
Maximal slope of rise (mV/ms) 261.3 ± 19.8 158.9 ± 11.4**
Maximal slope of fall (mV/ms) −39.6 ± 3.7 −21.9 ± 2.3**
AP amplitude (mV) 85.9 ± 2.8 68.2 ± 2.2**
  • AP, Action potential.

  • *p < 0.05,

  • **p < 0.01, t test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell resting membrane potential (mV) -71.2 ± 1.6 (20) -71.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell input resistance (MΩ) 363.4 ± 35.3 (20) 363.4 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell cell capacitance (pF) 105.5 ± 7.3 (20) 105.5 (pF) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell rheobase (pA) 90.9 ± 9.1 (20) 90.9 (pA) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell spike threshold (mV) -40.7 ± 1.6 (20) -40.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell first spike latency (s) 0.08 ± 0.02 (20) 80.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell AHP voltage (mV) -54.3 ± 1.9 (20) -54.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell spike half-width (ms) 1.58 ± 0.17 (20) 1.58 (ms) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell spike max rise slope (mV/ms) 261.3 ± 19.8 (20) 261.3 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell spike max decay slope (mV/ms) -39.6 ± 3.7 (20) 39.6 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 neocortex layer 5 large pyramidal cell spike amplitude (mV) 85.9 ± 2.8 (20) 85.9 (mV) Data Table