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Article: Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice.

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Kline DD; Ogier M; Kunze DL; Katz DM
J. Neurosci., 2010


Table 2.

Action potential properties in P35 Mecp2 wild-type and null mice

Mecp2 wild type Mecp2 null
Peak amplitude (mV) 67.32 ± 2.38 67.58 ± 2.88
Afterhyperpolarization (mV) −18.93 ± 1.46 −24.27 ± 2.50
Half-width (ms) 1.19 ± 0.13 0.91 ± 0.07
Threshold (mV) −34.66 ± 2.32 −32.22 ± 1.30
Rise time (10–90%, ms) 0.59 ± 0.07 0.51 ± 0.07
Rise slope (10–90%, mV/ms) 119.44 ± 15.87 119.94 ± 11.18
Decay time (90–10%, ms) 1.02 ± 0.12 0.67 ± 0.06*
Decay slope (90–10%, mV/ms) −61.96 ± 5.98 −91.76 ± 11.10*
  • Action potential properties were determined from current-induced depolarization. Data are derived from the initial action potential elicited at threshold.

  • *p < 0.05, t test. Data are mean ± SEM for wild type (n = 13 cells) and null (n = 15 cells).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus of the solitary tract principal cell spike amplitude (mV) 67.32 ± 2.38 (13) 67.32 (mV) Data Table
Nucleus of the solitary tract principal cell AHP amplitude (mV) -18.93 ± 1.46 (13) 18.93 (mV) Data Table
Nucleus of the solitary tract principal cell spike half-width (ms) 1.19 ± 0.13 (13) 1.19 (ms) Data Table
Nucleus of the solitary tract principal cell spike threshold (mV) -34.66 ± 2.32 (13) -34.66 (mV) Data Table
Nucleus of the solitary tract principal cell spike rise time 0.59 ± 0.07 (13) 0.59 (ms) Data Table
Nucleus of the solitary tract principal cell spike max rise slope 119.44 ± 15.87 (13) 119.44 (mV/ms) Data Table
Nucleus of the solitary tract principal cell spike decay time 1.02 ± 0.12 (13) 1.02 (ms) Data Table
Nucleus of the solitary tract principal cell spike max decay slope -61.96 ± 5.98 (13) 61.96 (mV/ms) Data Table