Article: Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Mu P; Moyer JT; Ishikawa M; Zhang Y; Panksepp J; Sorg BA; Schlüter OM; Dong Y J. Neurosci., 2010
Treatment | Saline i.p. | Cocaine i.p. | Saline SA | Cocaine SA |
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Number of cells | n = 9 | n = 11 | n = 8 | n = 13 |
Break-in RMP (mV) | −78.0 ± 1.3 | −76.6 ± 2.4 | −78.3 ± 1.0 | −74.0 ± 0.9** |
Stabilized RMP (mV) | −82.6 ± 0.4 | −83.5 ± 0.9 | −83.2 ± 1.0 | −81.3 ± 0.7 |
Ri at −100 pA (MΩ) | 130.4 ± 6.0 | 110.1 ± 4.2 | 133.0 ± 4.1 | 116.6 ± 3.6 |
Ri at +100 pA (MΩ) | 220.7 ± 4.4 | 189.5 ± 3.2 | 212.1 ± 2.4 | 202.3 ± 2.8 |
Latency, 1st spike (ms) | 173 ± 11 | 167 ± 31 | 188 ± 16 | 177 ± 9 |
Rheobase (pA) | 111 ± 11 (n = 7) | 160 ± 12 (n = 6)** | 115 ± 13 (n = 6) | 164 ± 6 (n = 7)** |
AP threshold (mV) | −33.9 ± 2.9 | −33.8 ± 2.1 | −33.4 ± 0.9 | −33.2 ± 0.7 |
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RMP, Resting membrane potential; Ri, input resistance; AP, action potential; Rheobase, minimal current that elicits an action potential along the duration (300 ms) of the test step.
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↵**p < 0.01.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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Nucleus accumbens shell neuron | resting membrane potential (mV) | -82.6 ± 0.4 (9) | -82.6 (mV) | Data Table | |
Nucleus accumbens shell neuron | input resistance (MΩ) | 130.4 ± 6.0 (9) | 130.4 (MΩ) | Data Table | |
Nucleus accumbens shell neuron | first spike latency (ms) | 173.0 ± 11.0 (9) | 173.0 (ms) | Data Table | |
Nucleus accumbens shell neuron | rheobase (pA) | 111.0 ± 11.0 (9) | 111.0 (pA) | Data Table | |
Nucleus accumbens shell neuron | spike threshold (mV) | -33.9 ± 2.9 (9) | -33.9 (mV) | Data Table |