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Article: Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons.

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Mu P; Moyer JT; Ishikawa M; Zhang Y; Panksepp J; Sorg BA; Schlüter OM; Dong Y
J. Neurosci., 2010


Table 1.

Membrane properties: 2 d withdrawal from intraperitoneal and SA cocaine administration

Treatment Saline i.p. Cocaine i.p. Saline SA Cocaine SA
Number of cells n = 9 n = 11 n = 8 n = 13
Break-in RMP (mV) −78.0 ± 1.3 −76.6 ± 2.4 −78.3 ± 1.0 −74.0 ± 0.9**
Stabilized RMP (mV) −82.6 ± 0.4 −83.5 ± 0.9 −83.2 ± 1.0 −81.3 ± 0.7
Ri at −100 pA (MΩ) 130.4 ± 6.0 110.1 ± 4.2 133.0 ± 4.1 116.6 ± 3.6
Ri at +100 pA (MΩ) 220.7 ± 4.4 189.5 ± 3.2 212.1 ± 2.4 202.3 ± 2.8
Latency, 1st spike (ms) 173 ± 11 167 ± 31 188 ± 16 177 ± 9
Rheobase (pA) 111 ± 11 (n = 7) 160 ± 12 (n = 6)** 115 ± 13 (n = 6) 164 ± 6 (n = 7)**
AP threshold (mV) −33.9 ± 2.9 −33.8 ± 2.1 −33.4 ± 0.9 −33.2 ± 0.7
  • RMP, Resting membrane potential; Ri, input resistance; AP, action potential; Rheobase, minimal current that elicits an action potential along the duration (300 ms) of the test step.

  • **p < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens shell neuron resting membrane potential (mV) -82.6 ± 0.4 (9) -82.6 (mV) Data Table
Nucleus accumbens shell neuron input resistance (MΩ) 130.4 ± 6.0 (9) 130.4 (MΩ) Data Table
Nucleus accumbens shell neuron first spike latency (ms) 173.0 ± 11.0 (9) 173.0 (ms) Data Table
Nucleus accumbens shell neuron rheobase (pA) 111.0 ± 11.0 (9) 111.0 (pA) Data Table
Nucleus accumbens shell neuron spike threshold (mV) -33.9 ± 2.9 (9) -33.9 (mV) Data Table