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Article: Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons.

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Mu P; Moyer JT; Ishikawa M; Zhang Y; Panksepp J; Sorg BA; Schlüter OM; Dong Y
J. Neurosci., 2010


Table 2.

Membrane properties: 3 week withdrawal from intraperitoneal administration

Treatment Saline w/d Cocaine w/d Saline w/d + cocaine Cocaine w/d + cocaine Acute cocaine
Number of cells n = 12 n = 16 n = 16 n = 16 n = 12
Break-in RMP (mV) −73.52 ± 0.8 −74.5 ± 0.7 −76.3 ± 0.5* −77.9 ± 0.8** −75.3 ± 0.7
Stabilized RMP (mV) −81.3 ± 0.7 −81.1 ± 0.5 −83.2 ± 0.6 −83.3 ± 0.6 −81.1 ± 0.9
Ri at −100 pA (MΩ) 137.6 ± 7.5 111.9 ± 5.1 101.8 ± 3.0 128.0 ± 2.5 103.1 ± 3.6
Ri at +100 pA (MΩ) 236.4 ± 5.3 211.7 ± 9.7 233.6 ± 6.6 249.3 ± 7.6 218.9 ± 8.1
Latency, 1st spike (ms) 188 ± 27 182 ± 34 174 ± 14 176 ± 14 171 ± 12
Rheobase (pA) 120 ± 15 (n = 5) 142 ± 11 (n = 8) 118 ± 10 (n = 6) 118 ± 16 (n = 7) 137 ± 7 (n = 4)
AP threshold (mV) −31.3 ± 0.9 −32.2 ± 1.2 −32.3 ± 0.5 −31.8 ± 0.9 −30.9 ± 0.6
  • RMP, Resting membrane potential; Ri, input resistance; AP, action potential; Rheobase, minimal current that elicits an action potential along the duration (300 ms) of the test step. RMP (mV):

  • *p < 0.05, saline w/d i.p. vs saline w/d i.p. + cocaine i.p.;

  • **p < 0.05, cocaine w/d i.p./cocaine w/d + cocaine i.p.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens shell neuron first spike latency (ms) 188.0 ± 27.0 188.0 (ms) Data Table
Nucleus accumbens shell neuron rheobase (pA) 120.0 ± 15.0 120.0 (pA) Data Table
Nucleus accumbens shell neuron spike threshold (mV) -31.3 ± 0.9 -31.3 (mV) Data Table