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Article: Calcium imaging in single neurons from brain slices using bioluminescent reporters.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Drobac E; Tricoire L; Chaffotte AF; Guiot E; Lambolez B
J. Neurosci. Res., 2010


Table II. Electrophysiological Properties (Mean ± SD) of Control and Sensors-Expressing Layer V Pyramidal Neurons
 Control (n = 8)GA (n = 12)GO (n = 18)GAN26D (n = 9)GAEGTA-free (n = 11)
  • *

    Statistically significant differences from control group (P < 0.05, Mann-Whitney test).

Resting membrane potential (mV)−60.6 ± 2.2−65.4 ± 3.5*−62.5 ± 2.5−61.4 ± 5.2−62.5 ± 2.4
Input resistance (MΩ)176.3 ± 79.4269.1 ± 130.2217.1 ± 46.1*187.8 ± 37.3189.1 ± 28.8
Spike threshold (mV)−40.1 ± 3.3−39.6 ± 2.4−38.8 ± 2.3−38.7 ± 2.9−38.6 ± 1.9
First spike amplitude (mV)108.9 ± 11.6106.3 ± 4.4107.7 ± 6.5106.4 ± 6.7106.7 ± 4.5
First spike duration (msec)1.2 ± 0.21.1 ± 0.21.2 ± 0.21.2 ± 0.11.1 ± 0.2
First AHP (mV)−10.8 ± 4.9−14.6 ± 4.2−12.3 ± 4.5−10.3 ± 2.8−10.9 ± 2.4

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Neocortex Layer V Pyramidal Cell spike threshold (mV) -40.1 ± 3.3 (8) -40.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex Layer V Pyramidal Cell spike amplitude (mV) 108.9 ± 11.6 (8) 108.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex Layer V Pyramidal Cell spike half-width (msec) 1.2 ± 0.2 (8) 1.2 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex Layer V Pyramidal Cell resting membrane potential (mV) -60.6 ± 2.2 (8) -60.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex Layer V Pyramidal Cell AHP amplitude (mV) -10.8 ± 4.9 (8) 10.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex Layer V Pyramidal Cell input resistance (MΩ) 176.3 ± 79.4 (8) 176.3 (MΩ) Data Table