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Article: A functional null mutation of SCN1B in a patient with Dravet syndrome.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL
J. Neurosci., 2009


Table 1.

Biophysical parameters of sodium current in HEKrNav1.1 cells compared with HEKrNav1.1 cells coexpressing β1WT or p.R125C

HEKrNav1.1 HEKrNav1.1 + β1WT HEKrNav1.1 + p.R125C
Voltage dependence of activation
    V1/2 (mV) −18.27 ± 1.53 −19.09 ± 1.79 −18.49 ± 0.92
    k −7.54 ± 0.35 −6.52 ± 0.54 −6.87 ± 0.26
    n 12 9 11
Voltage dependence of inactivation
    V1/2 (mV) −55.52 ± 1.32 −54.18 ± 0.77 −54.30 ± 1.47
    k 4.73 ± 0.22 4.59 ± 0.13 4.79 ± 0.21
    C 0.04 ± 0.01 0.05 ± 0.01 0.60 ± 0.01
    n 11 9 11
Kinetics of inactivation, one exponential
    τslow (ms) 0.63 ± 0.06 0.42 ± 0.03* 0.59 ± 0.03
    n 11 8 10
Kinetics of inactivation, two exponentials
    τslow (ms) 25.07 ± 12.99 6.95 ± 3.18 16.10 ± 8.68
    Amplitudeslow (%) 7.72 ± 1.65 4.43 ± 2.35 5.20 ± 4.84
    τfast (ms) 0.48 ± 0.05 0.34 ± 0.01 0.46 ± 0.02
    Amplitudefast (%) 92.27 ± 1.65 95.56 ± 2.35 94.79 ± 1.45
    n 11 8 10
  • Data are mean ± SEM.

  • *p < 0.05 compared with Nav1.1.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source