p.C121W |
Xenopus oocytes
|
Nav1.2
|
Similar functional modulation of α when injected at high concentration. Decreased modulation at lower concentration.b |
Meadows et al., 2002 |
|
1610 cells |
Nav1.3
|
Association with α. No shift in voltage dependence of current inactivation. Decreased frequency-dependent rundown. Acceleration
of recovery from fast inactivation.b No dominant-negative effect.
|
Meadows et al., 2002 |
|
1610 cells |
Nav1.2
|
Association with α. No shift in voltage dependence of current inactivation. No decrease in frequency-dependent rundown. Acceleration
of recovery from fast inactivation.b Equally effective as WT in promoting cell surface expression of α subunits.b |
Meadows et al., 2002 |
|
HEK-293 cells |
Nav1.4
|
Equally effective as wild type in promoting cell surface expression of α subunits.b |
Tammaro et al., 2002 |
|
|
|
Unable to accelerate recovery from inactivation.a |
|
|
|
|
Channels containing p.C121W may require larger-than-normal stimuli to open but, once activated, inactivate considerably less
readily than channels containing wild-type β1.
|
Aman et al., 2009 |
|
HEK-293 cells |
Nav1.1
|
|
|
p.I70-E74del |
N/A |
N/A |
N/A |
Audenaert et al., 2003 |
p.R85C |
HEK-293 cells |
Nav1.2
|
No modulation of current density. |
Xu et al., 2007 |
|
|
|
Inability to shift voltage dependence of fast activation, fast or slow inactivation, decrease time constant of fast inactivation,
or accelerate recovery from fast inactivation.b No protein expression detected.b |
|
p.R85H |
HEK-293 cells |
Nav1.2
|
No modulation of current density. Inability to shift voltage dependence of fast activation or inactivation or accelerate recovery
from fast inactivation.b No protein expression detected.b |
Xu et al., 2007 |
p.R125C |
HEK-293 cells |
Nav1.1
|
Reduced cell surface expression.b |
Present paper |
|
1610 cells |
Nav1.2
|
Decreased sodium current density.b Inability to shift voltage dependence of inactivation. Reduced frequency-dependent rundown, accelerated recovery from fast
inactivation, increased persistent current.b Reduced cell surface expression.b |
Present paper |
|
Xenopus oocytes
|
Nav1.2
|
Channel modulation similar to wild type. |
Present paper |