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Article: Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease.

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Cummings DM; André VM; Uzgil BO; Gee SM; Fisher YE; Cepeda C; Levine MS
J. Neurosci., 2009


Table 2.

Basic membrane properties of pyramidal neurons in YAC128 and CAG140 KI mice

6 month YAC128 (CsMeth) 12 month YAC128 (CsMeth) 12 month CAG140 KI (CsMeth)
WT (n = 15) YAC128 (n = 26) WT (n = 8) YAC128 (n = 8) WT (n = 8) KI (n = 7)
Rm (MΩ) 105 ± 11 173 ± 22* 127 ± 16 206 ± 12*** 104 ± 16 171 ± 31*
τ (ms) 2.0 ± 0.2 2.2 ± 0.1 2.6 ± 0.2 2.3 ± 0.2 2.1 ± 0.02 2.9 ± 0.3
Cm (pF) 100 ± 10 93 ± 5 106 ± 11 95 ± 5 96 ± 11 102 ± 6
  • In each column, data for WT and mutant mice are presented. n values are indicated in parentheses. Significance is indicated by *p < 0.05; ***p < 0.001.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source