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Article: Experimental early-life febrile seizures induce changes in GABA(A) R-mediated neurotransmission in the dentate gyrus.

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Swijsen A; Avila A; Brône B; Janssen D; Hoogland G; Rigo JM
Epilepsia, 2012


Table 1.   Membrane properties of dentate granule cells of normothermia (NT) animals and hyperthermia animals with (HT+BFS) and without (HT−BFS) seizures
Electrophysiologic propertyNTHT−BFSHT+BFS

  1. Experiments on dentate granule cells were carried out 6–9 days after normothermia/hyperthermia treatment. Data are presented as means ± SEM with n in parentheses. Membrane properties of dentate granule cells do not differ between NT, HT−BFS, and HT+BFS animals (analyzed using one-way ANOVA and post hoc Bonferroni multiple comparison test).

Resting membrane potential (mV)−62.8 ± 0.2 (17)−62.4 ± 0.3 (8)−62.5 ± 0.1 (15)
Input resistance (GΩ)1.0 ± 0.2 (14)1.3 ± 0.2 (23)1.4 ± 0.2 (22)
Membrane capacitance (pF)25.1 ± 2.5 (14)32.1 ± 2.8 (23)30.3 ± 3.2 (22)

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus granule cell cell capacitance (pF) 25.1 ± 2.5 (14) 25.1 (pF) Data Table
Dentate gyrus granule cell resting membrane potential (mV) -62.8 ± 0.2 (17) -62.8 (mV) Data Table
Dentate gyrus granule cell input resistance (GΩ) 1.0 ± 0.2 (14) 1000.0 (MΩ) Data Table