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Article: Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Okaty BW; Miller MN; Sugino K; Hempel CM; Nelson SB
J. Neurosci., 2009


Table 1.

GO overrepresentation analysis reveals enrichment of specific categories of molecular function among developmentally upregulated (top) and downregulated (bottom) genes

GO term (molecular function) p value Found/total
Upregulated genes
    Transporter activity 0.004 101/1454
        Channel or pore class transporter activity 0.003 34/386
            Ion transporter activity 8 × 10−6 62/655
                Ion channel activity 2 × 10−4 34/330
                    Voltage-gated ion channel activity 2 × 10−6 25/163
                        Voltage-gated potassium channel activity 6 × 10−5 16/98
                    Cation channel activity 3 × 10−5 29/237
                        Potassium channel activity 2 × 10−5 20/130
                Metal ion transporter activity 0.003 11/77
                Cation transporter activity 4 × 10−6 53/518
    Potassium ion binding 5 × 10−4 14/95
    Magnesium ion binding 5 × 10−5 32/281
    Catalytic activity 5 × 10−5 311/4879
        Oxidoreductase activity, acting on NADH or NADPH 0.007 9/64
        Kinase activity 0.007 65/890
    Inositol or phosphatidylinositol phosphatase activity 0.008 6/33
        Phosphoinositide 5-phosphatase activity 0.001 3/5
    Acetylglucosaminyltransferase activity 0.004 5/21
Downregulated genes
    Protein binding 1 × 10−4 207/3733
        RNA binding 6 × 10−5 44/533
        Calmodulin binding 0.002 12/105
        Cytoskeletal protein binding 5 × 10−5 31/325
    Structural constituent of ribosome 2 × 10−4 23/228
    Oxidoreductase activity, acting on paired donors 4 × 10−4 4/9
    Calcium channel regulator activity 0.002 4/13
    Voltage-gated calcium channel activity 0.009 4/19
    Voltage-gated sodium channel activity 0.001 4/12

  • Hierarchical relationship of GO terms is denoted by indentation. p values were calculated using the hypergeometric probability distribution, which computes the probability of finding a given GO term in the list of differentially expressed genes (found), given the total number of genes on the Affymetrix GeneChip annotated with that term (total). All terms with p < 0.01 are shown.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source