Article: Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents.
Table 2Effect of OAG and TPM on membrane and firing parametersa
n
AP slope (V/s)
AP amplitude (mV)
AP repolarisation (V/s)
Rn (MΩ)
Tau (ms)
Threshold stimulus (nA)
Control
5
322.1±23.0
103.7±3.3
115.8±12.0
34.1±3.2
10.7±0.3
0.19±0.04
TPM
306.3±22.2(*)
99.0±3.4
110.0±12.7
32.9±2.0
11.9±0.9
0.23±0.4(*)
Washout
313.2±24.1
105.3±2.1
118.8±7.5
31.6±2.3
11.4±1.0
0.19±0.4
Control
6
304.6±20.1
105.0±3.0
137.3±8.1
30.7±2.4
11.2±0.7
0.22±0.07
OAG
301.3±14.8
104.3±1.7
134.0±11.6
31.0±0.9
11.1±0.6
0.17±0.03(*)
TPM+OAG
292.0±9.7
101.6±3.5
132.2±6.6
26.1±3.6
11.2±1.0
0.19±0.04
TPM washout
4
295.±17.5
100.3±4.4
124.0±4.7
38.1±3.0
9.1±0.5
0.20±0.06
(*)P<0.05 (in comparison with values measured under control conditions).aRn=membrane input resistance; Tau=membrane time constant; Threshold stimulus=amplitude of the depolarising current pulse needed to reach the firing threshold.
