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Article: Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Brown RE; Winston S; Basheer R; Thakkar MM; McCarley RW Neuroscience, 2006
Table 1Summary of properties of rat subcoeruleus (SubC) neurons
Parameters in bold indicate those properties which distinguish each group of neurons. Abbreviations: AP, action potential; CARB, carbachol; f, firing frequency; Rin, input resistance; RMP, resting membrane potential; TTP, time-to-peak; TyH, tyrosine hydroxylase.
| Property | Putative cholinergic (n=19) | TyH positive (n=9) | CARB-E (n=27) | CARB-I LTS (n=22) | CARB-I A-current (n=8) |
| Long-axis diameter (μm) | 29.9±1.5 | 26.6±1.6 | 24.7±1.1 | 20.3±0.6 | 19.0±1.3 |
| Short-axis diameter (μm) | 14.2±0.8 | 16.7±1.1 | 12.9±0.9 | 9.8±0.3 | 11.0±1.0 |
| RMP (mV) | −62.2±1.1 | −60.6±0.8 | −61.6±1.1 | −65.4±1.5 | −60.0±4.0 |
| Rin (MΩ) | 337±28 | 411±95 | 406±47 | 407±37 | 833±254 |
| AP width (ms) | 3.2±0.3 | 2.9±0.9 | 2.7±0.3 | 2.5±0.3 | 3.7±0.4 |
| AP rise time (ms) | 0.8±0.1 | 1.2±0.4 | 1.1±0.2 | 0.9±0.1 | 1.4±0.2 |
| AP threshold (mV) | −54.1±1.0 | −48.5±1.9 | −52.8±1.8 | −50.0±1.1 | −52.3±4.0 |
| AP height (mV) | 70.5±4.1 | 61.3±2.8 | 57.5±2.5 | 58.4±3.1 | 54.3±4.8 |
| AHP amplitude (mV) | −16.4±0.9 | −25.1±1.8 | −19.0±1.4 | −16.2±1.9 | −14.3±2.4 |
| sAHP amplitude (mV) | −12.6±1.5 | −16.3±1.5 | −9.1±0.9 | −8.0±0.8 | −6.5±2.0 |
| % Sag | 54.1±1.8 | 97.3±1.5 | 75.0±1.9 | 83.0±2.2 | 82.4±1.3 |
| Delay (ms) | 57±8 | 470±127 | 71±8 | 58±6 | 240±35 |
| LTS amplitude (mV) | 15.7±1.7 | — | 12.3±1.6 | 20.0±1.7 | — |
| LTS TTP (ms) | 63±10 | — | 119±14 | 64±7 | — |
| Spontaneous f (Hz) | 2.5±0.7 | 1.2±0.3 | 6.5±0.7 | — | 5.1±2.7 |
| Maximum f (Hz) | 43±4 | 39±6 | 52±4 | 49±4 | 32±3 |
| Effect of CARB | Inhibition | Excitation | Excitation | Inhibition | Inhibition |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | cell diameter (μm) | 14.2 ± 0.8 (19) | 14.2 (um) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | cell diameter (μm) | 16.7 ± 1.1 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | resting membrane potential (mV) | -62.2 ± 1.1 (19) | -62.2 (mV) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | resting membrane potential (mV) | -60.6 ± 0.8 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | input resistance (MΩ) | 337.0 ± 28.0 (19) | 337.0 (MΩ) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | input resistance (MΩ) | 411.0 ± 95.0 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | spike width (ms) | 3.2 ± 0.3 (19) | 3.2 (ms) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | spike width (ms) | 2.9 ± 0.9 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | spike rise time (ms) | 0.8 ± 0.1 (19) | 0.8 (ms) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | spike rise time (ms) | 1.2 ± 0.4 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | spike threshold (mV) | -54.1 ± 1.0 (19) | -54.1 (mV) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | spike threshold (mV) | -48.5 ± 1.9 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | spike amplitude (mV) | 70.5 ± 4.1 (19) | 70.5 (mV) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | spike amplitude (mV) | 61.3 ± 2.8 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | AHP amplitude (mV) | -16.4 ± 0.9 (19) | 16.4 (mV) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | AHP amplitude (mV) | -25.1 ± 1.8 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | slow AHP amplitude (mV) | -12.6 ± 1.5 (19) | 12.6 (mV) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | slow AHP amplitude (mV) | -16.3 ± 1.5 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | sag ratio | 54.1 ± 1.8 (19) | 0.541 (ratio) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | sag ratio | 97.3 ± 1.5 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | cell diameter (μm) | 29.9 ± 1.5 (19) | 29.9 (um) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | cell diameter (μm) | 26.6 ± 1.6 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | spontaneous firing rate (Hz) | 2.5 ± 0.7 (19) | 2.5 (Hz) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | spontaneous firing rate (Hz) | 1.2 ± 0.3 (9) | -- | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus cholinergic neurons | maximum firing rate (Hz) | 43.0 ± 4.0 (19) | 43.0 (Hz) | Data Table |
| Other | Dorsolateral pontine rostral subcoeruleus nucleus tyrosine hydroxylase-positive cholinergic neurons | maximum firing rate (Hz) | 39.0 ± 6.0 (9) | -- | Data Table |