Table 1Intrinsic membrane properties of medial and lateral perforant pathway projection neurons
RMP (mV)
RN (MΩ)
τ (ms)
Sag ratio
Threshold (mV)
AP width (ms)
AP amplitude (mV)
AHP (mV)
n
Medial
−65.3±0.3
84±14
16.6±1.7
0.72±0.02
−52.6±0.6
1.2±0.0
106±1
8.5±0.5
12–52
Lateral
−66.6±0.4
204±22
43.3±5.0
0.95±0.01
−51.7±0.3
1.2±0.0
96±1
16.4±0.6
12–42
P<0.01
*
*
*
*
*
RMP, resting membrane potential; RN, input resistance; τ, membrane time constant; Sag ratio, voltage deflection at steady-state divided by the peak voltage deflection during large (>10 mV) square hyperpolarizing current injections; Threshold, action potential threshold; AP width, action potential width measured at threshold; AP amplitude, action potential amplitude from threshold; AHP, fast afterhyperpolarization amplitude below threshold; n, number of cells (range). RN and τ were measured using voltage responses (<5 mV) to square hyperpolarizing current injections in the presence of 2>3 mM extracellular CsC1 to avoid activation of voltage-dependent conductances. Values are mean±S.E.M.; P values are derived from unpaired t-tests.
