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Article: Spike-timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depends on target cell type.

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Lu JT; Li CY; Zhao JP; Poo MM; Zhang XH
J. Neurosci., 2007


Table 1.

Properties of FS and LTS interneurons

FS (n) LTS (n)
Membrane resistance (MΩ) 94.3 ± 4.7 (31) 399.6 ± 28.6 (30)
Spike half-width (ms) 0.85 ± 0.02 (31) 1.36 ± 0.08 (30)
AHP amplitude (mV)a 23.1 ± 0.6 (31) 14.1 ± 0.6 (30)
Threshold current (pA)bf 269 ± 17 (31) 43 ± 3 (30)
Onset frequency (Hz)c 26.6 ± 1.5 (31) 11.7 ± 1.4 (30)
I/O slope (Hz/pA)df 0.30 ± 0.01 (21) 0.09 ± 0.01 (19)
Spike frequency adaptationef 1.07 ± 0.01 (21) 2.05 ± 0.20 (19)
  • Membrane characteristics and firing properties of FS and LTS cells in layer 2/3 of somatosensory cortex. n, Number of cells examined (p < 0.001 for all parameters, Student's ttest).

  • aAfterhyperpolarization (AHP), calculated as the difference between the action potential threshold and the most negative level reached during the repolarizing phase.

  • bCurrent injections with duration 600 ms in 20 pA steps from 0 to 600 pA. The threshold current was the amplitude of the first step current to evoke action potentials.

  • cOnset frequency was the spike frequency of the action potential trains elicited by the threshold current.

  • dThe I/O slope is the slope of the input (injected current) minus output (firing frequency) curve, with the amplitude of the injected currents ranging from 300 to 600 pA.

  • eSpike-frequency adaptation, calculated as the mean of the ratios of the instantaneous frequencies at the fourth and the last spike intervals in every action potential train elicited by step-current injections from 300 to 600 pA.

  • fRanges completely nonoverlapping.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell somatosensory cortex layer 2/3 fast-spiking cell rheobase (pA) 269.0 ± 17.0 (31) 269.0 (pA) Data Table
Neocortex Martinotti cell somatosensory cortex layer 2/3 low-threshold spiking cell rheobase (pA) 43.0 ± 3.0 (30) 43.0 (pA) Data Table
Neocortex basket cell somatosensory cortex layer 2/3 fast-spiking cell firing frequency (Hz) 26.6 ± 1.5 (31) 26.6 (Hz) Data Table
Neocortex Martinotti cell somatosensory cortex layer 2/3 low-threshold spiking cell firing frequency (Hz) 11.7 ± 1.4 (30) 11.7 (Hz) Data Table
Neocortex basket cell somatosensory cortex layer 2/3 fast-spiking cell FI slope (Hz/pA) 0.3 ± 0.01 (21) 300.0 (Hz/nA) Data Table
Neocortex Martinotti cell somatosensory cortex layer 2/3 low-threshold spiking cell FI slope (Hz/pA) 0.09 ± 0.01 (19) 90.0 (Hz/nA) Data Table
Neocortex basket cell somatosensory cortex layer 2/3 fast-spiking cell input resistance (MΩ) 94.3 ± 4.7 (31) 94.3 (MΩ) Data Table
Neocortex basket cell somatosensory cortex layer 2/3 fast-spiking cell adaptation ratio (last/first ISI) 1.07 ± 0.01 (21) 1.07 (ratio) Data Table
Neocortex Martinotti cell somatosensory cortex layer 2/3 low-threshold spiking cell adaptation ratio (last/first ISI) 2.05 ± 0.2 (19) 2.05 (ratio) Data Table
Neocortex Martinotti cell somatosensory cortex layer 2/3 low-threshold spiking cell input resistance (MΩ) 399.6 ± 28.6 (30) 399.6 (MΩ) Data Table
Neocortex basket cell somatosensory cortex layer 2/3 fast-spiking cell spike half-width (ms) 0.85 ± 0.02 (31) 0.85 (ms) Data Table
Neocortex Martinotti cell somatosensory cortex layer 2/3 low-threshold spiking cell spike half-width (ms) 1.36 ± 0.08 (30) 1.36 (ms) Data Table
Neocortex basket cell somatosensory cortex layer 2/3 fast-spiking cell AHP amplitude (mV) 23.1 ± 0.6 (31) 23.1 (mV) Data Table
Neocortex Martinotti cell somatosensory cortex layer 2/3 low-threshold spiking cell AHP amplitude (mV) 14.1 ± 0.6 (30) 14.1 (mV) Data Table