Article: Spike-timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depends on target cell type.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Lu JT; Li CY; Zhao JP; Poo MM; Zhang XH J. Neurosci., 2007
FS (n) | LTS (n) | |
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Membrane resistance (MΩ) | 94.3 ± 4.7 (31) | 399.6 ± 28.6 (30) |
Spike half-width (ms) | 0.85 ± 0.02 (31) | 1.36 ± 0.08 (30) |
AHP amplitude (mV)a | 23.1 ± 0.6 (31) | 14.1 ± 0.6 (30) |
Threshold current (pA)bf | 269 ± 17 (31) | 43 ± 3 (30) |
Onset frequency (Hz)c | 26.6 ± 1.5 (31) | 11.7 ± 1.4 (30) |
I/O slope (Hz/pA)df | 0.30 ± 0.01 (21) | 0.09 ± 0.01 (19) |
Spike frequency adaptationef | 1.07 ± 0.01 (21) | 2.05 ± 0.20 (19) |
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Membrane characteristics and firing properties of FS and LTS cells in layer 2/3 of somatosensory cortex. n, Number of cells examined (p < 0.001 for all parameters, Student's ttest).
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↵aAfterhyperpolarization (AHP), calculated as the difference between the action potential threshold and the most negative level reached during the repolarizing phase.
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↵bCurrent injections with duration 600 ms in 20 pA steps from 0 to 600 pA. The threshold current was the amplitude of the first step current to evoke action potentials.
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↵cOnset frequency was the spike frequency of the action potential trains elicited by the threshold current.
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↵dThe I/O slope is the slope of the input (injected current) minus output (firing frequency) curve, with the amplitude of the injected currents ranging from 300 to 600 pA.
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↵eSpike-frequency adaptation, calculated as the mean of the ratios of the instantaneous frequencies at the fourth and the last spike intervals in every action potential train elicited by step-current injections from 300 to 600 pA.
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↵fRanges completely nonoverlapping.