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Article: Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.

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Mathon DS; Lesscher HM; Gerrits MA; Kamal A; Pintar JE; Schuller AG; Spruijt BM; Burbach JP; Smidt MP; van Ree JM; Ramakers GM
Neuroscience, 2005


Table 1Nose poke responding during the 10 minutes pre-test for the MOR knockout and wild-type micea
Cocaine (μg/infusion)
0.40.81.6
WT
Active50.3±8.262.9±8.241.4±8.2
Yoked53.6±13.452.0±13.038.9±7.9
KO
Active39.2±11.156.2±5.846.8±9.4
Yoked53.7±6.955.1±7.439.0±7.0
aData are expressed as mean±S.E.M. nose poke responses during 10 min per genotype per type (active or yoked) per dose.

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