Table 2Summary of effects of chronic ethanol treatment on passive membrane properties at 15 DIV
Control (n=14)
Chronic ethanol (n=16)
Resting membrane potential (mV)
−51±1
−52±1
Input resistancea
Peak hyperpolarization (MΩ)
339±16
297±16b
Sustained hyperpolarization (MΩ)
197±10
181±11
Sustained depolarization (MΩ)
135±15
130±13
aInput resistances were calculated separately from the slopes of the input–output curves generated by injecting standardized constant current pulses (±30 to ±150 pA; 500 ms) and measuring the peak and sustained voltage in response to hyperpolarizing current and the sustained voltage in response to depolarizing current.bIndicates a trend for the chronic ethanol treatment group to be different from the control group (0.05≤P<0.10, unpaired t-test); other measurements were not affected by chronic ethanol (P>0.10). All values are the mean±S.E.M. and represent combined data from studies performed in the presence and absence of TTX.
