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Article: Transgenic mouse lines subdivide medial vestibular nucleus neurons into discrete, neurochemically distinct populations.

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Bagnall MW; Stevens RJ; du Lac S
J. Neurosci., 2007


Table 3.

Glutamatergic and glycinergic YFP-16 neurons exhibit physiology similar to each other but not to glycinergic GIN neurons

YFP-16 GIN
VGluT2+ GlyT2+ GlyT2− GlyT2+
AP width (ms) 0.52 ± 0.09 0.53 ± 0.08 0.78 ± 0.13 0.73 ± 0.13
AP half-width (ms) 0.20 ± 0.04 0.21 ± 0.04 0.33 ± 0.08 0.32 ± 0.07
AHP (mV) 19.9 ± 2.8 20.2 ± 2.0 27.0 ± 3.0* 23.8 ± 4.4*
Maximum derivative (V/s) 536 ± 117 494 ± 132 341 ± 70 340 ± 93
Minimum derivative (V/s) 472 ± 104 445 ± 136 255 ± 70 259 ± 94
ADP (V/s) 7.54 ± 5.58 5.3 ± 3.32 −2.09 ± 1.86 −1.48 ± 2.51
Threshold (mV) −50.9 ± 2.6 −50.1 ± 2.2 n/a n/a
Input resistance (MΩ) 46 ± 19* 67 ± 19* 248 ± 136 230 ± 127
Maximum firing rate (Hz) 398 ± 136 355 ± 82 145 ± 32 169 ± 68
Adaptation ratio @40 Hz 0.72 ± 0.12 0.79 ± 0.08 0.91 ± 0.08 0.92 ± 0.09
Gain <80 Hz (Hz/nA) 178 ± 63 222 ± 74 240 ± 71 239 ± 120
Gain >80 Hz (Hz/nA) 98 ± 37 134 ± 37 202 ± 64 185 ± 99
Gain/input resistance 2.27 ± 0.74 2.06 ± 0.44 0.97 ± 0.39 1.12 ± 0.44
Rebound firing (Hz) 52 ± 32* 21 ± 16* 11 ± 8 8 ± 7
  • Left columns indicate the physiology of YFP-16 neurons subjected to RT-PCR. Spike parameters, n = 9 (each group); cell parameters, n = 7–9. Right columns indicate the physiology of GIN neurons that underwent RT-PCR. Most neurons expressed both GAD67 and GAD65; the data here are divided into those neurons that did or did not coexpress GlyT2 (spike parameters, n = 14, each group; cell parameters, n = 11–14). Data represent a separate pool of neurons than those analyzed in Table 2. Asterisks indicate p < 0.05 compared to neurons from the same transgenic line. Values indicate mean ± SD.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron spike width (ms) 0.52 ± 0.09 (9) 0.52 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike width (ms) 0.53 ± 0.08 (9) 0.53 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron spike width (ms) 0.78 ± 0.13 (14) 0.78 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike width (ms) 0.73 ± 0.13 (14) 0.73 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron spike half-width (ms) 0.2 ± 0.04 (9) 0.2 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike half-width (ms) 0.21 ± 0.04 (9) 0.21 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron spike half-width (ms) 0.33 ± 0.08 (14) 0.33 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike half-width (ms) 0.32 ± 0.07 (14) 0.32 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron AHP amplitude (mV) 19.9 ± 2.8 (9) 19.9 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron AHP amplitude (mV) 20.2 ± 2.0 (9) 20.2 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron AHP amplitude (mV) 27.0 ± 3.0 (14) 27.0 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron AHP amplitude (mV) 23.8 ± 4.4 (14) 23.8 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron spike max rise slope (V/s) 536.0 ± 117.0 (9) 536.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike max rise slope (V/s) 494.0 ± 132.0 (9) 494.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron spike max rise slope (V/s) 341.0 ± 70.0 (14) 341.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike max rise slope (V/s) 340.0 ± 93.0 (14) 340.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron spike max decay slope (V/s) 472.0 ± 104.0 (9) 472.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike max decay slope (V/s) 445.0 ± 136.0 (9) 445.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron spike max decay slope (V/s) 255.0 ± 70.0 (14) 255.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike max decay slope (V/s) 259.0 ± 94.0 (14) 259.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron ADP amplitude (V/s) 7.54 ± 5.58 (9) -- Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron ADP amplitude (V/s) 5.3 ± 3.32 (9) -- Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron ADP amplitude (V/s) -2.09 ± 1.86 (14) -- Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron ADP amplitude (V/s) -1.48 ± 2.51 (14) -- Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron spike threshold (mV) -50.9 ± 2.6 (9) -50.9 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron spike threshold (mV) -50.1 ± 2.2 (9) -50.1 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron input resistance (MΩ) 46.0 ± 19.0 (9) 46.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron input resistance (MΩ) 67.0 ± 19.0 (9) 67.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron input resistance (MΩ) 248.0 ± 136.0 (14) 248.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron input resistance (MΩ) 230.0 ± 127.0 (14) 230.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron maximum firing rate (Hz) 398.0 ± 136.0 (9) 398.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron maximum firing rate (Hz) 355.0 ± 82.0 (9) 355.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron maximum firing rate (Hz) 145.0 ± 32.0 (14) 145.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron maximum firing rate (Hz) 169.0 ± 68.0 (14) 169.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron adaptation ratio (Hz) 0.72 ± 0.12 (9) 0.72 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron adaptation ratio (Hz) 0.79 ± 0.08 (9) 0.79 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron adaptation ratio (Hz) 0.91 ± 0.08 (14) 0.91 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron adaptation ratio (Hz) 0.92 ± 0.09 (14) 0.92 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic neuron FI slope (Hz/nA) 98.0 ± 37.0 (9) 98.0 (Hz/nA) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron FI slope (Hz/nA) 134.0 ± 37.0 (9) 134.0 (Hz/nA) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus non-glycinergic neuron FI slope (Hz/nA) 202.0 ± 64.0 (14) 202.0 (Hz/nA) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glycinergic neuron FI slope (Hz/nA) 185.0 ± 99.0 (14) 185.0 (Hz/nA) Data Table