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Article: Evidence of altered inhibition in layer V pyramidal neurons from neocortex of Kcna1-null mice.

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van Brederode JF; Rho JM; Cerne R; Tempel BL; Spain WJ
Neuroscience, 2001


Table 1Comparison of the intrinsic properties of layer V pyramidal neurons from wild-type (+/+) and Kcna1-null (−/−) mice*
+/+ (n=5)−/− (n=6)
RMP, mV−69.8±3.48−70.7±4.14
RN, MΩ116.6±18.781.7±10.1
AP Amplitude, mV95.6±1.8690.3±6.58
AP Threshold, mV−38.2±2.60−44.7±2.86
AP Width at base, ms1.14±0.111.17±0.21
AP Half-width, ms0.70±0.040.72±0.11
*Values are reported as mean±S.E.M. Number of neurons is indicated in parentheses; RN, input resistance calculated from peak voltage responses to small (5–10mV) hyperpolarizing current pulses; RMP, resting membrane potential; AP, action potential; AP Amplitude, peak AP amplitude measured from RMP; AP Threshold, AP threshold relative to RMP measured from the inflection point just prior to the AP upstroke; AP Width at base, width of the AP measured at threshold; AP Half-width, width of the AP measured at a point halfway between threshold and peak.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 pyramidal neuron spike amplitude from resting (mV) 95.6 ± 1.86 (5) 95.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 pyramidal neuron spike threshold (mV) -38.2 ± 2.6 (5) -38.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 pyramidal neuron spike width (ms) 1.14 ± 0.11 (5) 1.14 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 pyramidal neuron spike half-width (ms) 0.7 ± 0.04 (5) 0.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 pyramidal neuron resting membrane potential (mV) -69.8 ± 3.48 (5) -69.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 pyramidal neuron input resistance (MΩ) 116.6 ± 18.7 (5) 116.6 (MΩ) Data Table