Article: Evidence of altered inhibition in layer V pyramidal neurons from neocortex of Kcna1-null mice.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) van Brederode JF; Rho JM; Cerne R; Tempel BL; Spain WJ Neuroscience, 2001
Table 1Comparison of the intrinsic properties of layer V pyramidal neurons from wild-type (+/+) and Kcna1-null (−/−) mice*
*Values are reported as mean±S.E.M. Number of neurons is indicated in parentheses; RN, input resistance calculated from peak voltage responses to small (5–10mV) hyperpolarizing current pulses; RMP, resting membrane potential; AP, action potential; AP Amplitude, peak AP amplitude measured from RMP; AP Threshold, AP threshold relative to RMP measured from the inflection point just prior to the AP upstroke; AP Width at base, width of the AP measured at threshold; AP Half-width, width of the AP measured at a point halfway between threshold and peak.
+/+ (n=5) | −/− (n=6) | |
RMP, mV | −69.8±3.48 | −70.7±4.14 |
RN, MΩ | 116.6±18.7 | 81.7±10.1 |
AP Amplitude, mV | 95.6±1.86 | 90.3±6.58 |
AP Threshold, mV | −38.2±2.60 | −44.7±2.86 |
AP Width at base, ms | 1.14±0.11 | 1.17±0.21 |
AP Half-width, ms | 0.70±0.04 | 0.72±0.11 |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | spike amplitude from resting (mV) | 95.6 ± 1.86 (5) | 95.6 (mV) | Data Table |
Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | spike threshold (mV) | -38.2 ± 2.6 (5) | -38.2 (mV) | Data Table |
Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | spike width (ms) | 1.14 ± 0.11 (5) | 1.14 (ms) | Data Table |
Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | spike half-width (ms) | 0.7 ± 0.04 (5) | 0.7 (ms) | Data Table |
Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | resting membrane potential (mV) | -69.8 ± 3.48 (5) | -69.8 (mV) | Data Table |
Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | input resistance (MΩ) | 116.6 ± 18.7 (5) | 116.6 (MΩ) | Data Table |