Table 2Specific [3H]MK-801 (17 nM) binding in VH compared to DH as determined by quantitative autoradiography
Region
DH, fmol/mg tissue
VH, fmol/mg tissue
CA1
Stratum oriens
157±12
85±11(*↓ 46%)
Stratum radiatum
152±12
99±11(*↓ 35%)
CA3
Stratum oriens
103±9
73±9(*↓ 29%)
Stratum radiatum
99±11
75±9(*↓ 24%)
DG
Molecular layer: internal
134±10
106±12(*↓21%)
Molecular layer: external
143±11
116±13(*↓19%)
Data are mean±S.E. obtained from six to 10 animals (measurements are derived from at least six sections per animal). Statistically significant differences between VH and DH are indicated as * P<0.05 (paired t-test). Numbers in parentheses indicate the percentage of the lower levels.