Table 3Values of EPSP, IE and AP (mean±SD) before and after HFS in type-A and type-B neurons in the presence of antagonists for NMDAR (AP-5), AMPAR (NBQX) and mGluR1(CPCCOEt)
Type-A neurons
AP-5 (n=5)
AP-5+NBQX(n=0)
CPCCOEt (n=2)
Control
HFS
Control
HFS
EPSP
Amplitude (mV)
3.2±1.2
3.2±1.2
2.8±0.1
3.5±0.07
Slope (mV/ms)
0.64±0.12
0.64±0.12
0.44±0.002
0.55±0.01
Decay time constant τ (ms)
50.4±12.3
50.4±12.3
44.9±0.6
54.5±1.9
AP-5 (n=4)
AP-5+NBQX (n=3)
CPCCOEt (n=4)
Control
HFS
Control
HFS
Control
HFS
IE
SF (spikes/s)
2.5±0.4
3.3±0.6
2.6±0.5
3.1±0.4
2.8±1.2
0.4±0.1
EF (spikes)
12.2±3.5
19.5±5.7
12.1±1.1
16.8±3.3
12.3±6.2
3±1.8
Rin (MΩ)
640.4±37.1
716.7±4.4
640±9.1
749.4±66.3
639.9±57.1
160.1±30.3
AP
AHP amplitude (mV)
−20.3±1.3
−17.4±3.4
−20.2±1.2
−17.5±1.8
−20.3±0.6
−22.6±1.2
ISS (mv/s)
50.75±2.4
57.4±3.2
52.6±4
54.34±3.9
56.86±3.1
9.04±2.4
Type-B neurons
AP-5 (n=7)
AP-5+NBQX (n=0)
CPCCOEt (n=4)
Control
HFS
Control
HFS
Control
HFS
EPSP
Amplitude (mV)
4.92±1.2
4.92±1.2
4.2±0.3
5.8±0.4⁎
Slope (mV/ms)
1.16±0.5
1.18±0.5
1.25±0.1
1.63±0.1⁎
Decay time constant τ (ms)
15.3±5.4
15.3±5.4
18.6±0.4
25.3±2⁎
AP-5 (n=7)
AP-5+NBQX (n=3)
CPCCOEt (n=3)
Control
HFS
Control
HFS
Control
HFS
IE
SF (spikes/s)
5.4±1.37
8.2±3.7⁎
5.5±1.8
8.6±4.1⁎
4.8±2.5
2.1±1.5⁎
EF (spikes)
13.7±2.5
25±4.7
13.6±1.2
24.3±4.8
12.6±4.8
8.2±5.3⁎
Rin (MΩ)
271.7±38.5
366.4±50
237.8±50.6
330.7±90.7
270.6±12.4
189.5±37⁎
AP
AHP amplitude (mV)
−16.9±0.7
−13.6±1.9
−16.8±0.9
−13.7±1.3
−16.8±1.6
−19.5±3.2
ISS (mv/s)
110.5±5.5
138.3±9.3⁎
110±11.3
151.8±14.2⁎
49.1±3.7⁎
⁎Indicates significant difference (ANOVA and Tukey's post hoc test, P<0.05) in the change induced by HFS between type-A and type-B neurons.