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Article: A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.

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Otto JF; Yang Y; Frankel WN; White HS; Wilcox KS
J. Neurosci., 2006


Table 1.

Intrinsic electrophysiological properties of CA1 neurons recorded in brain slices prepared from B6 and Szt1 mice

Membrane property B6 n Szt1 n
Resting membrane potential (mV) −60.1 ± 0.4 19 −59.7 ± 0.4 19
Holding current at −20 mV (pA) 261 ± 22 28 280 ± 31 31
Input resistance (MΩ) 111 ± 4 38 105 ± 4 40
Series resistance (MΩ) 13.2 ± 0.5 38 13.4 ± 0.5 40
Spike half-width (ms) 1.52 ± 0.04 19 1.53 ± 0.04 18
Spike threshold (mV) −46.2 ± 0.7 19 −45.0 ± 0.7 18
IK(M) deactivation kinetics (τ in ms) 157 ± 13 17 140 ± 15 17
  • None of the parameters measured differed between CA1 neurons in slices prepared from B6 and Szt1 mice (p > 0.5, ANOVA). Resting membrane potential, input resistance, and series resistance were taken from values reported by SealTest and MultiClamp Commander functions. Spike half-width and spike threshold values were calculated from the first action potential that was generated in response to the lowest depolarizing current injection. > values were calculated by fitting the IK(M) deactivation phase with a single-exponential equation.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance (MΩ) 111.0 ± 4.0 (25) 111.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell access resistance (MΩ) 13.2 ± 0.5 (25) 13.2 (MΩ) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -60.1 ± 0.4 (25) -60.1 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.52 ± 0.04 (25) 1.52 (ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -46.2 ± 0.7 (25) -46.2 (mV) Data Table
Hippocampus CA1 pyramidal cell membrane time constant 157.0 ± 13.0 (25) 157.0 (ms) Data Table