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Article: Changes in membrane properties of CA1 pyramidal neurons after transient forebrain ischemia in vivo.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Gao TM; Pulsinelli WA; Xu ZC Neuroscience, 1999
Table 3Membrane properties of small excitatory postsynaptic potential neurons at different periods after ischemia
*Values are means±S.D., with number of neurons in parentheses. Spike height is measured from the resting membrane potential. Spike width is measured at half of the peak amplitude of the action potential. Input resistance (Rin) is derived from the linear portion of the current–voltage curve (0 to −0.5nA). Time constant is derived from transients of hyperpolarizing pulse (−0.3nA, 200ms). RMP, resting membrane potential.**P<0.05, **P<0.01, ANOVA.
| Reperfusion | RMP | Spike height | Spike width | Rin | Time constant | Spont. firing |
| (mV) | (mV) | (ms) | (MΩ) | (ms) | (Hz) | |
| Before | −73±6.28 (22) | 77±7.52 (22) | 0.82±0.20 (22) | 25.63±5.51 (15) | 12.44±2.88 (15) | 0.53±0.58 (16) |
| ∼31h after | −71±7.21 (7) | 78±12.11 (5) | 0.85±0.20 (5) | 15.73±11.34* (4) | 7.35±3.49** (4) | 0.00±0.00** (7) |
| ∼42h after | −69±5.32 (4) | 77±16.26 (3) | 0.75±0.21 (3) | 12.50±10.54* (3) | 6.57±6.03** (3) | 0.01±0.03** (4) |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 small excitatory postsynaptic potential pyramidal neurons | resting membrane potential | -73.0 ± 6.28 (22) | -73.0 (mV) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 small excitatory postsynaptic potential pyramidal neurons | spike amplitude from resting | 77.0 ± 7.52 (22) | 77.0 (mV) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 small excitatory postsynaptic potential pyramidal neurons | spike half-width | 0.82 ± 0.2 (22) | 0.82 (ms) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 small excitatory postsynaptic potential pyramidal neurons | input resistance | 25.63 ± 5.51 (15) | 25.63 (MΩ) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 small excitatory postsynaptic potential pyramidal neurons | membrane time constant | 12.44 ± 2.88 (15) | 12.44 (ms) | Data Table |
| Hippocampus CA1 pyramidal cell | Hippocampus CA1 small excitatory postsynaptic potential pyramidal neurons | spontaneous firing rate | 0.53 ± 0.58 (16) | 0.53 (Hz) | Data Table |