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Article: Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade.

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Takei H; Fujita S; Shirakawa T; Koshikawa N; Kobayashi M
Neuroscience, 2010


Table 2Effects of blockers of kinases on intrinsic electrophysiological properties of layerII/III pyramidal cells
ControlLavendustin AWortmanninDeguelinPD 98059
Mean±SEMnMean±SEMnMean±SEMnMean±SEMnMean±SEMn
Vm† (mV)−73.5±2.220−79.8±3.26−74.8±1.523−78.1±2.58−78.0±2.315
Input resistance (MΩ)28.3±1.72014.7±2.5⁎⁎⁎628.2±1.61820.1±2.1⁎626.8±2.115
Rheobase (nA)0.55±0.06190.78±0.0660.67±0.05160.79±0.1360.71±0.0613
f/I slope (Hz/nA)23.7±2.31915.4±2.1618.6±2.7169.2±1.2⁎⁎620.8±3.913
†Resting membrane potential.⁎P<0.05,⁎⁎P<0.01,⁎⁎⁎P<0.001(Student's t-test).

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Insular cortex layer 2-3 pyramidal cells resting membrane potential (mV) -73.5 ± 2.2 -73.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Insular cortex layer 2-3 pyramidal cells input resistance (MΩ) 28.3 ± 1.7 28.3 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Insular cortex layer 2-3 pyramidal cells rheobase (nA) 0.55 ± 0.06 550.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Insular cortex layer 2-3 pyramidal cells FI slope (Hz/nA) 23.7 ± 2.3 23.7 (Hz/nA) Data Table